Sentences with phrase «mechanistic model for»

A Mechanistic Model for Rational Design of Optimal Cellulase Mixtures, Seth Levine, Jerome Fox, Douglas Clark, Harvey Blanch, Biotechnology and Bioengineering, 108 (11), pp. 2561 - 2570, doi: 10.1002 / bit.23249, November 2011.

Based on this information, the team developed a conceptual mechanistic model for how uraninite would react in groundwater.

Since scientists first decoded a draft of the human genome more than 15 years ago, many questions have lingered, two of which have been addressed in a major new study co-led by a Princeton University computer scientist: Is it possible, despite the complexity of billions of bits of genetic information and their variations between people, to develop a mechanistic model for how healthy bodies function?

They incorporated the lifecycle of phytoplankton and zooplankton — small, often microscopic animals at the bottom of the food chain — into a novel mechanistic model for assessing the global ocean carbon export.

They were convinced that one could get further and discover more by employing a mechanistic model for what even they felt obliged to call «living» phenomena.

Not exact matches

2 He suggested that scientists are moving away from a mechanistic model of the universe which has dominated their thinking for more than two hundred years.

Illustrative of mechanistic thinking 75 years ago are the fantastic models of ether molecules devised to account for the properties of light transmission.

The church opted for the mechanistic model of the universe, though in many respects the organic view would have been much more supportive of Christian faith.

«The new animal model opens the door for scientists to conduct needed mechanistic studies and identify preventative therapies to minimize this painful and debilitating condition,» Banga said.

An extension of this model, however, proposes that EMT forms a key mechanistic basis for the progression of malignant tumors (reviewed by Nieto MA [1]-RRB-.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.

Previous work has given insights into the mechanistic pathways leading to small molecule sequestration in membrane - free coacervate protocells; successfully demonstrated the use of liquid - liquid phase separated micro compartments for protein expression using cell free expression systems; exploited microfluidics for the high throughput formation of stable, monodisperse microdroplets; and integrated two contrasting modes of protocell construction to produce a novel hybrid model based on fatty acid membrane - bound coacervate micro-droplets.

Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems, which may have implications for understanding disease and development.

As we demonstrate here, climate models provide new insights into the historical, current, and future populations of marine turtles and provide a mechanistic modeling framework for considering anthropogenic climate change.

We reconstructed the full carbonate system of an estuarine seagrass habitat for a summer period of 2.5 months utilizing a combination of time - series observations and mechanistic modeling, and quantified the roles of aerobic metabolism, mixing, and gas exchange in the observed dynamics.

For example, many mechanistic models used to simulate the ecological effects of climate change operate at spatial resolutions varying from a single plant to a few hectares.

Conclusion If we follow George Box's scientific advice, then a logical, unifying, next step for «stadium wave» models is to collaborate with computational / mechanistic global climate models to answer this simple question: By appropriate adjustment of parameters, can mechanistic climate models exhibit stadium waves?

However, most of the current Earth system models that predict climate change and C cycle feedbacks lack both a mechanistic formulation for height - structured competition for light and an explicit scaling from individual plants to the globe.

Woodburn, a hydrogeologist by training, along with Carl Steefel, head of Berkeley Lab's Geochemistry Department, will develop a mechanistic numerical model of the Cosumnes River watershed, which extends from the Sierra Nevada to south of Sacramento, ultimately feeding into the Sacramento - San Joaquin River Delta and the California State Water Project, the major source of water for much of Southern California.

Its full narrative includes: the coupling multi-century climate — cosmogenic nuclides increasingly detected, the way this coupling is not just a matter of climate - dependent nuclides transport and deposition, the way ocean lag disqualifies flagship narratives about recent shorter - term modelling purportedly ruling this out, and, the way a 20th century grand maximum would call for a mechanistic incorporation of all this in 20th century understanding / modelling — only, the mechanism (UV or GCR - clouds, probably the former) has not been well enough understood yet.

Modeling has an enormous virtue, (at least to me) because you can break down the system into pieces, and simply deal in a mechanistic fashion with heat and mass transfer for each of your n compartments.

The Guidance Note for Lead Authors of the IPCC Fifth Assessment Report on Consistent Treatment of Uncertainties impose upon the lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g., mechanistic understanding, theory, data, models, expert judgment) and the degree of agreement.

The research aims for mechanistic understanding of the processes important to the decadal modulation of ENSO and tropical Pacific decadal variability through model experiments and observational analysis.