Sentences with phrase «mechanistic studies in»

The Institute seeks hypothesis - driven, mechanistic studies in both immunology and tumor immunology.

Research Project Grant (R01) applications proposing to conduct mechanistic studies in humans and animal models on alcohol - induced transgenerational effects and the role of epigenetic inheritance in these effects.

Research Project Grant (R01) applications proposing to conduct mechanistic studies in humans and animal models on the relationships between alcohol abuse, circadian rhythms and sleep disorders.

Not exact matches

«The depth and breadth of evidence now implicating cow's milk as a cause of Type 1 diabetes is overwhelming, even though the very complex mechanistic details are not yet fully understood,» T. Colin Campbell wrote in «The China Study.»

«Mechanistic finding may help develop treatment for Ice Bucket Challenge disease: Study blames a fault in the cell's machine that cuts and pastes genetic instructions for a deadly motor neuron disease.»

«Our study is an important step in identifying the mechanistic relationship between TBI and post-traumatic epilepsy.

«This study provides conclusive, mechanistic evidence that ERAD plays an important role in restraining Alzheimer's disease pathology.

From the in vitro reconstituted Rad3 - Rad26 complex, small - angle X-ray scattering and electron microscopic studies, it is possible to model the quaternary structure and thus bring us closer to a mechanistic understanding Rad3 - Rad26 DNA repair apparatus.

Mechanistic studies reveal that amTOR, a stimulatory gene in caste differentiation, is the direct target of miR162a.

That's why I think the mechanistic studies are so important to try to only target the TGF - beta receptor signaling in the primary cilia but not in other parts of the body,» says Ogretmen.

«It is important to begin mechanistic studies of these declines,» the team concludes in a paper presenting the finding published in today's Science, «with habitat alteration, climate change and agricultural chemical usage being potential key drivers of observed shifts.»

Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.

A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case.

Now two studies published in the journal Alcoholism: Clinical and Experimental Research suggest that they may in fact share similar mechanistic pathways in the brain.

These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.

Since scientists first decoded a draft of the human genome more than 15 years ago, many questions have lingered, two of which have been addressed in a major new study co-led by a Princeton University computer scientist: Is it possible, despite the complexity of billions of bits of genetic information and their variations between people, to develop a mechanistic model for how healthy bodies function?

«The behavioral measures give you perspective on whether a treatment could actually work in helping improve the communicative abilities of older adults, while biological or auditory electrophysiology measures give you an indication of the actual mechanistic pathways that the training may be affecting,» says Frank Lin, an otolaryngologist at Johns Hopkins University in Baltimore, Maryland, who was not involved in the study.

«Peer behavior is perhaps the most enduring social correlate of both contemporaneous and subsequent alcohol use, so studies specifically designed to explore the etiology underlying these associations, and particularly those that examine mechanistic processes, are tremendously important to the field,» added Shawn J. Latendresse, assistant professor in the department of psychology & neuroscience at Baylor University.

To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conserved secondary structure adjacent to the template.

«In this study, we identified a novel regulatory factor for the Golgi - ER retrograde transport and a new mechanistic connection between the physiological trafficking and the autophagic transportation of cellular material.»

They go on to say that «since no single broadly neutralizing antibody combines the entire range of mechanistic features anticipated to support in vivo efficacy, our study adds further evidence that combinations of such antibodies need to be considered for human application.»

There is a clear need for further mechanistic studies to explore the role of PREX2 and mutations of PREX2 in cancer.

Also, through these studies we solidified the mechanistic understanding for how p53 functions in the cytosol, which complements its pro-apoptotic role in the nucleus.»

FOA encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol - induced organ damage.

Validating this original concept, we previously demonstrated that PGD - derived hES cells and their derivatives, which express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic mechanistic analysis ranging from functional studies at the cellular level to a large - scale drug screening.

The study of BIN1 in the brain is a new area of research and determining the mechanistic link between this risk factor and AD etiology disease is important.

Chen J, Ghorai MK, Kenney G, Stubbe J. Mechanistic studies on bleomycin - mediated DNA damage: multiple binding modes can result in double - stranded DNA cleavage.

Validating this concept, we previously demonstrated that human pluripotent stem cells and derivatives which, express the causal mutation implicated in the Myotonic Dystrophy type 1 (DM1), offer pertinent disease - cell models, applicable for a wide systemic analysis ranging from mechanistic studies to therapeutic screening.

Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.

During her residency in Human Genetics at the University of Bonn she pursued her research interest both in immunology and human genetics by investigating expression quantitative trait loci (eQTLs), which underpin innate immune responses, and provide mechanistic insights to complement genome - wide association studies.

«This is a perfect example of how studying a different type of virus at the mechanistic level in the long run can completely apply to the HIV system,» he said.

Our mechanistic studies, in both mouse and human mammary cancer cells, indicate that leptin and LepR are necessary for NANOG expression.

Visit the Frontiers of Photobiology: Nobel Lecture by Aziz Sancar (The Nobel Prize in Chemistry 2015 «for mechanistic studies of DNA repair») Nobel Lecture by Roger Y. Tsien (The Nobel Prize in Chemistry 2008 «for the discovery and development of the green fluorescent protein, GFP») Interviews with Johann Deisenhofer, Robert Huber, Hartmut Michel (The Nobel Prize in Chemistry 1988 «for the determination of the three - dimensional structure of a photosynthetic reaction centre»)

Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio - temporal control of genomic methylation specificity, including components of histone modification and RNA - directed pathways (small and long).

In this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performeIn this way, in - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performein - depth immunological monitoring, genetic and proteomic analyses, and biomarker discovery from patient samples guides further laboratory investigation, where mechanistic studies can be designed and animal modeling performed.

Spectroscopy & Application of Lasers, Zare / Moerner / +, 6 - 1 Nuclear Hormone Signaling, Chambon / Evans / Jensen, 6 - 1 Bioinorganic Chemistry, Gray / Lippard / Holm / — , 8 - 1 The Field (everything not listed), 10 - 1 Techniques in DNA Synthesis, Caruthers / Hood / +, 10 - 1 Electrochemistry / Electron Transfer, Bard / Hush / Gray / — , 19 - 1 Instrumentation / Techniques in Genomics, Venter / +, 19 - 1 Biological Membrane Vesicles, Rothman / Schekman / +, 19 - 1 Molecular Studies of Gene Recognition, Ptashne, 19 - 1 Organic Electronics, Tang / +, 39 - 1 Polymer Science, Matyjaszewski / Langer / + / — 69 - 1 Solar Cells, Grätzel / +, 74 - 1 Mechanistic Enzymology, Walsh / Stubbe / Koshland / + / — , 74 - 1 Combinatorial Chemistry / DOS, Schreiber / +, 99 - 1 Pigments of Life, Battersby / +, 99 - 1 Development of the Birth Control Pill, Djerassi, 99 - 1 Molecular Modeling and Assorted Applications, Karplus / Houk / Schleyer / Miller / + / — , 99 - 1 Applications of NMR Spectroscopy, Pines / Roberts / McConnell / + / — , 99 - 1 Development of Chemical Biology, Schultz / Schreiber / +, 99 - 1 Self - Assembly, Whitesides / Nuzzo / Stang / — , 149 - 1 Small Regulatory RNA, Ambros / Baulcombe / Ruvkun, 149 - 1 Nanotechnology, Lieber / Whitesides / Alivisatos / Mirkin / Seeman / + / — , 149 - 1 Eukaryotic RNA Polymerases, Roeder, 149 - 1 Contributions to Theoretical Physical Chemistry, Rice / +, 149 - 1 Mechanical Bonds and Applications, Sauvage / Stoddart / +, 149 - 1 Bio - & Organo - catalysis, List / Lerner / Barbas / + / — , 149 - 1 Organic Synthesis, Evans / Danishefsky / Nicolaou / Ley / Trost / Stork / Wender / Kishi / + / — , 199 - 1 Leptin, Coleman / Friedman / Leong, 199 - 1 Fluorocarbons, DuPont / Curran / — , 199 - 1 Understanding of Organic Stereochemistry, Mislow, 199 - 1 Tissue Engineering, Langer / +, 199 - 1 Contributions to Bioorganic Chemistry, Breslow / Eschenmoser / +, 199 - 1 Dendrimers, Frechet / Tomalia / +, 399 - 1 Zeolites, Flanigan, 399 - 1 Molecular Recognition, Dervan / +, 399 - 1 Molecular Machines, Stoddart / Tour / + / — , 399 - 1 Astrochemistry, Oka, 999 - 1

Experimental studies of a purely phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ.

Mechanistic studies indicated the protective effect of amylin required interaction with its cognate... receptor because silencing the amylin receptor expression blocked the amylin effect on Cd68 in microglia.

The results are «important both for mechanistic study and also for potentially therapeutic developments,» said Yadong Huang of the University of California, San Francisco, and the Gladstone Institute of Neurological Disease, who also was not involved in the work.

Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study deStudy designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study destudy design.

Studies are in animal behavior from mechanistic and evolutionary perspectives by using fruit flies, bees, and other insects.

Until the publication of this study, several mechanistic details of how the low - complexity domain of hnRNPA2 worked and how it changed into aggregates in disease were unknown.

Dynamic STCH cycle and in - operando mechanistic and kinetic studies of redox oxides.

As the mechanistic studies suggest that ER - α and Notch are central in mediating the unfavourable hypoxic CSC response in ER - α — positive breast cancer, they may offer an attractive combination treatment approach, which would consist of ER - α or Notch inhibitors combined with antiangiogenic drugs.

The study has earned high marks from researchers not on the soy industry's payroll, including Dan Sheehan, PhD and Daniel Doerge, PhD at the FDA's National Laboratory for Toxicological research in Jefferson, Arkansas.who stated, «Given the great difficulty in discerning the relationship between exposures and long latency adverse effects in the human population and the potential mechanistic explanation for the epidemiological findings, this is an important study.

Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies.

Conversely, other acute studies in humans have yielded possible mechanistic insights.

«Future studies can provide mechanistic understanding by examining how specific compounds in coffee are involved in telomere maintenance.»

The current results provide a potential mechanistic understanding for the observed differences between Vitamin C in supplements vs food in prior studies.

«This is something that could be explained in quite a mechanistic way,» said Giorgio Vallortigara, a neuroscientist and an author of both studies.