Sentences with phrase «mechanistic studies of»
Mechanistic studies of dimethylsulfide oxidation products using an observationally constrained model
http://www.pnas.org/
Mechanistic studies of FMc - derived protection against breast cancer are warranted.
Visit the Frontiers of Photobiology: Nobel Lecture by Aziz Sancar (The Nobel Prize in Chemistry 2015 «for mechanistic studies of DNA repair») Nobel Lecture by Roger Y. Tsien (The Nobel Prize in Chemistry 2008 «for the discovery and development of the green fluorescent protein, GFP») Interviews with Johann Deisenhofer, Robert Huber, Hartmut Michel (The Nobel Prize in Chemistry 1988 «for the determination of the three - dimensional structure of a photosynthetic reaction centre»)
Introduced in 1992 by Kim and Chung (1), spinal nerve L5 / L6 ligation (SNL) in rats has become well recognized and accepted as an animal model for mechanistic studies of peripheral neuropathy and for screening of novel analgesics.
FOA encourages applications that propose to conduct mechanistic studies of the circadian rhythms involved in alcohol - induced organ damage.
«It is important to begin mechanistic studies of these declines,» the team concludes in a paper presenting the finding published in today's Science, «with habitat alteration, climate change and agricultural chemical usage being potential key drivers of observed shifts.»
«It makes it much easier for researchers working with barley to be focused on attainable objectives, ranging from new variety development through breeding to mechanistic studies of genes.»
Mechanistic Study of USP15 - Dependent Deubiquitination and Characterization of Natural Compounds that Modulate the Nrf2 - Keap1 Antioxidant Response.
Not exact matches
vows the outer cover of one mechanistic study.41 Contextual inquiry presented an ethical critique of parish life; mechanistic studies provided the engineering to empower parish life.
One thing seems beyond peradventure: the mechanistic conception breaks of its own weight when one studies any process» (CSR 396).
«The depth and breadth of evidence now implicating cow's milk as a cause of Type 1 diabetes is overwhelming, even though the very complex mechanistic details are not yet fully understood,» T. Colin Campbell wrote in «The China Study.»
Nineteen adult volunteers with and without a history of atopic dermatitis were recruited into two randomized forearm - controlled mechanistic studies.
Mechanistic studies reveal that amTOR, a stimulatory gene in caste differentiation, is the direct target of miR162a.
That's why I think the mechanistic studies are so important to try to only target the TGF - beta receptor signaling in the primary cilia but not in other parts of the body,» says Ogretmen.
«This new study extends those original mechanistic findings to the amyloid pathway and preservation of cellular and synaptic connections.
«This study shows, that there is a mechanistic explanation for why fish may move, faced with a choice, and now we have a way of testing it,» Johansen said.
A new study published in Proceedings of the National Academy of Sciences and led by researchers from the University of Pennsylvania now offers the first mechanistic explanation for why this is the case.
These findings also suggest a mechanistic basis for potential treatments involving the painless electrical stimulation of the amygdala, which are currently being studied in ongoing clinical trials.
Since scientists first decoded a draft of the human genome more than 15 years ago, many questions have lingered, two of which have been addressed in a major new study co-led by a Princeton University computer scientist: Is it possible, despite the complexity of billions of bits of genetic information and their variations between people, to develop a mechanistic model for how healthy bodies function?
«The behavioral measures give you perspective on whether a treatment could actually work in helping improve the communicative abilities of older adults, while biological or auditory electrophysiology measures give you an indication of the actual mechanistic pathways that the training may be affecting,» says Frank Lin, an otolaryngologist at Johns Hopkins University in Baltimore, Maryland, who was not involved in the study.
«Peer behavior is perhaps the most enduring social correlate of both contemporaneous and subsequent alcohol use, so studies specifically designed to explore the etiology underlying these associations, and particularly those that examine mechanistic processes, are tremendously important to the field,» added Shawn J. Latendresse, assistant professor in the department of psychology & neuroscience at Baylor University.
To understand how telomerase RNA participates in mechanistic aspects of telomere synthesis, we studied a conserved secondary structure adjacent to the template.
Policymaking committees should consider giving less weight to food industry - funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development,» the article concludes.
«In this study, we identified a novel regulatory factor for the Golgi - ER retrograde transport and a new mechanistic connection between the physiological trafficking and the autophagic transportation of cellular material.»
Notophthalmus viridescens, an urodelian amphibian, represents an excellent model organism to study regenerative processes, but mechanistic insights into molecular processes driving regeneration have been hindered by a paucity and poor annotation of coding nucleotide sequences.
They go on to say that «since no single broadly neutralizing antibody combines the entire range of mechanistic features anticipated to support in vivo efficacy, our study adds further evidence that combinations of such antibodies need to be considered for human application.»
There is a clear need for further mechanistic studies to explore the role of PREX2 and mutations of PREX2 in cancer.
This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.
The American Journal of Physiology - Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems.
«Long - term projections of the type presented here are always crude caricatures but I like this study because it does take a more mechanistic approach based on the known habitat requirements of the species rather than using a more traditional and simplistic thermal envelope model,» he said.
The study of BIN1 in the brain is a new area of research and determining the mechanistic link between this risk factor and AD etiology disease is important.
Research Project Grant (R01) applications proposing to conduct mechanistic studies in humans and animal models on alcohol - induced transgenerational effects and the role of epigenetic inheritance in these effects.
Dr. Sibley added, «Identification of important pathogenesis determinants on a genome - wide level will foster mechanistic studies on the function of key parasite virulence factors and help to improve diagnosis and treatment of toxoplasmosis.»
During her residency in Human Genetics at the University of Bonn she pursued her research interest both in immunology and human genetics by investigating expression quantitative trait loci (eQTLs), which underpin innate immune responses, and provide mechanistic insights to complement genome - wide association studies.
«This is a perfect example of how studying a different type of virus at the mechanistic level in the long run can completely apply to the HIV system,» he said.
Hyman, a former director of the National Institute of Mental Health, calls it «the most significant mechanistic study about schizophrenia ever.»
Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori - induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.
Specific mechanistic studies include an interrogation of the adhesion dynamics controlled by the tetraspanin CD151 and affiliated adhesion receptors (Integrins and IgG cell adhesion receptors).
Studying DNA methylation in the window of conception leads also to mechanistic insights into the spatio - temporal control of genomic methylation specificity, including components of histone modification and RNA - directed pathways (small and long).
Spectroscopy & Application of Lasers, Zare / Moerner / +, 6 - 1 Nuclear Hormone Signaling, Chambon / Evans / Jensen, 6 - 1 Bioinorganic Chemistry, Gray / Lippard / Holm / — , 8 - 1 The Field (everything not listed), 10 - 1 Techniques in DNA Synthesis, Caruthers / Hood / +, 10 - 1 Electrochemistry / Electron Transfer, Bard / Hush / Gray / — , 19 - 1 Instrumentation / Techniques in Genomics, Venter / +, 19 - 1 Biological Membrane Vesicles, Rothman / Schekman / +, 19 - 1 Molecular Studies of Gene Recognition, Ptashne, 19 - 1 Organic Electronics, Tang / +, 39 - 1 Polymer Science, Matyjaszewski / Langer / + / — 69 - 1 Solar Cells, Grätzel / +, 74 - 1 Mechanistic Enzymology, Walsh / Stubbe / Koshland / + / — , 74 - 1 Combinatorial Chemistry / DOS, Schreiber / +, 99 - 1 Pigments of Life, Battersby / +, 99 - 1 Development of the Birth Control Pill, Djerassi, 99 - 1 Molecular Modeling and Assorted Applications, Karplus / Houk / Schleyer / Miller / + / — , 99 - 1 Applications of NMR Spectroscopy, Pines / Roberts / McConnell / + / — , 99 - 1 Development of Chemical Biology, Schultz / Schreiber / +, 99 - 1 Self - Assembly, Whitesides / Nuzzo / Stang / — , 149 - 1 Small Regulatory RNA, Ambros / Baulcombe / Ruvkun, 149 - 1 Nanotechnology, Lieber / Whitesides / Alivisatos / Mirkin / Seeman / + / — , 149 - 1 Eukaryotic RNA Polymerases, Roeder, 149 - 1 Contributions to Theoretical Physical Chemistry, Rice / +, 149 - 1 Mechanical Bonds and Applications, Sauvage / Stoddart / +, 149 - 1 Bio - & Organo - catalysis, List / Lerner / Barbas / + / — , 149 - 1 Organic Synthesis, Evans / Danishefsky / Nicolaou / Ley / Trost / Stork / Wender / Kishi / + / — , 199 - 1 Leptin, Coleman / Friedman / Leong, 199 - 1 Fluorocarbons, DuPont / Curran / — , 199 - 1 Understanding of Organic Stereochemistry, Mislow, 199 - 1 Tissue Engineering, Langer / +, 199 - 1 Contributions to Bioorganic Chemistry, Breslow / Eschenmoser / +, 199 - 1 Dendrimers, Frechet / Tomalia / +, 399 - 1 Zeolites, Flanigan, 399 - 1 Molecular Recognition, Dervan / +, 399 - 1 Molecular Machines, Stoddart / Tour / + / — , 399 - 1 Astrochemistry, Oka, 999 - 1
Experimental studies of a purely phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ.
The discovery of CDHR3 as the probable receptor for RV - C opens the way for biological and mechanistic studies.
Mechanistic studies indicated the protective effect of amylin required interaction with its cognate... receptor because silencing the amylin receptor expression blocked the amylin effect on Cd68 in microglia.
From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
The results are «important both for mechanistic study and also for potentially therapeutic developments,» said Yadong Huang of the University of California, San Francisco, and the Gladstone Institute of Neurological Disease, who also was not involved in the work.
Study designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study deStudy designs, both large scale clinical trials as well as smaller mechanistic studies, will take into consideration and take advantage of the heterogeneity of clinical phenotypes in the study destudy design.
The results provide a valuable resource for future studies aimed at a mechanistic understanding of the function of O - GlcNAc on specific proteins during T cell activation.
Mechanistic studies indicated the protective effect of amylin required interaction with its cognate
Knowledge gained from mechanistic studies may contribute to the design of allogeneic vaccine - based or adoptive immunotherapy for breast cancer.
We chose to highlight a diverse set of biological processes and experimental systems to make the point that the principles of cross species analysis of basic gene function extend to the study of all human disorders, and can lead to mechanistic understanding of disease pathogenesis and rationale for the development of new therapies.