Sentences with phrase «mechanistic target»

The role of mechanistic target of rapamycin (MTOR) signaling in this process is poorly understood, even though MTOR is known to determine brain size.

Whitehead Institute scientists have at last answered the long - standing question of how the growth - regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine — itself a key player in modulating muscle growth, appetite, and insulin secretion.

Her main research interests lie with investigating key signaling mechanisms in retinal pigment epithelium, with the focus on the pathway mediated by mechanistic target of rapamycin (mTOR), and to identify molecular targets that can potentially be translated into interventional targets for treating chronic ocular diseases such as AMD.

Whitehead Institute researchers have elucidated how the growth - regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine.

It is well known that seizures produce learning, memory and behavioral deficits, and that they trigger abnormally high activity of two signaling pathways in the brain: the phosphoinositide 3 - kinase (PI3K) and mechanistic target of rapamycin (mTOR) cascades.

The authors also found that viral persistence in CSF correlated with the activation of the mechanistic target of rapamycin (mTOR) pathway, which has been shown to be related to the development of brain tissue and brain malformations.

Rapamycin gave mTOR its name — mechanistic target of rapamycin.

Scientists from the Growth Factors, Nutrients and Cancer Group at the Spanish National Cancer Research Center (CNIO), led by Nabil Djouder, have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR (the mammalian / mechanistic Target of Rapamycin); a protein that is altered in human diseases such as cancer and diabetes, processes associated with aging, as well as in certain cardiovascular and neurodegenerative pathologies.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

Buck President and CEO Brian Kennedy, PhD has performed ground - breaking research on aging in mice, specifically focusing on a nutrient - sensing pathway called mTOR (mechanistic Target of Rapamycin).

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

The protein complex GATOR1 (for «GAP activity toward Rags») inhibits the mTOR (for «mechanistic target of rapamycin complex 1») pathway.

Mechanistic target of rapamycin (mTOR) is a key regulatory protein that controls the balance between cellular anabolism and catabolism.

-- Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

One enzyme, RagA, has been found to regulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway in cells according to glucose and amino acid availability.

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway — which senses the availability of nutrients — to coordinate their growth with existing environmental conditions.

Abbreviations: ER, endoplasmic reticulum; GLUT, glucose transporter; H&E, haematoxylin and eosin; IL, interleukin; mTOR, mechanistic target of rapamycin; mTORC1, mTOR complex 1; VEGF, vascular endothelial growth factor

Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].

The mechanistic target of rapamycin (mTOR) and the silent mating - type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders

BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.