Sentences with phrase «mechanistic target of»

IGF - I is perhaps the most important mediator of muscle growth and repair (49), possibly through the use of protein kinase B — mechanistic target of rapamycin — p70 ribosomal protein S6 kinase signaling.

BETHESDA, MD, — The Foundation for the National Institutes of Health (FNIH) has selected Whitehead Institute Member David Sabatini to receive its fifth annual Lurie Prize in Biomedical Sciences for discovery of the mTOR (mechanistic target of rapamycin) cellular pathway as a key regulator of growth and metabolism in response to nutrients.

The role of mechanistic target of rapamycin (MTOR) signaling in this process is poorly understood, even though MTOR is known to determine brain size.

The mechanistic target of rapamycin (mTOR) and the silent mating - type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders

Tumour cells are «glutamine - addicted» [1,2] because glutamine is coupled to mechanistic target of rapamycin (mTOR) signalling, which integrates signals from growth factors, energy status and amino acid nutrition and co-ordinates these signals with cell growth, cell cycle progression and antioxidant machinery [3].

Whitehead Institute researchers have elucidated how the growth - regulating metabolic pathway known as mTORC1 (for mechanistic target of rapamycin complex 1) senses the amino acid arginine.

Cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway — which senses the availability of nutrients — to coordinate their growth with existing environmental conditions.

One enzyme, RagA, has been found to regulate the mechanistic target of rapamycin complex 1 (mTORC1) pathway in cells according to glucose and amino acid availability.

Mechanistic target of rapamycin (mTOR) is a key regulatory protein that controls the balance between cellular anabolism and catabolism.

The protein complex GATOR1 (for «GAP activity toward Rags») inhibits the mTOR (for «mechanistic target of rapamycin complex 1») pathway.

When the mTORC1 (for «mechanistic target of rapamycin complex 1») pathway operates properly, it senses the amount of nutrients, specifically amino acids, available and restricts cell growth based on that level.

Mechanistic target of rapamycin (mTOR): Alterations to the mTOR gene and levels of protein produced have been shown to modestly extend life span in several species.

Known as much for its complexity as its vital role in regulating cellular and organismal growth, the mechanistic target of rapamycin complex 1 (mTORC1) pathway has seemingly been acting in mysterious ways.

Whitehead Institute scientists have at last answered the long - standing question of how the growth - regulating pathway known as mechanistic target of rapamycin complex 1 (mTORC1) detects the presence of the amino acid leucine — itself a key player in modulating muscle growth, appetite, and insulin secretion.

To coordinate their size and growth with current environmental conditions, cells rely on the mechanistic target of rapamycin complex 1 (mTORC1) pathway, which senses cellular stresses, growth factors, and the availability of nutrients, such as amino acids and glucose.

Rapamycin gave mTOR its name — mechanistic target of rapamycin.

Not exact matches

The government wants a mechanistic way of describing how something hits the central nervous system and then affects mood and thought, but there's no way of documenting that without resorting to talk of «brain» and «mind», and even if there was, plenty of substances we don't want to target - like taurine, nutmeg or incense - would be covered by it too.

The mechanistic modelling, treatment of people as resources, obsession with the short - term, and management by targets in the public sector are all symptoms of the sick ideology that has driven management culture, which Simon brilliantly dissected.

«Having identified a link between cytoskeleton dynamics and Zika virus replication, together with the plethora of available cytoskeleton - targeting compounds, might contribute to gain mechanistic insight into the ZIKV replication cycle and identify new avenues for treatment,» Bartenschlager says.

Mechanistic studies reveal that amTOR, a stimulatory gene in caste differentiation, is the direct target of miR162a.

Now that the pieces are being connected and the role of prostaglandin is established, Wingert will turn attention to gaining a deeper molecular and mechanistic understanding of how the molecule works in kidney development, especially the gene targets of the signaling.

That's why I think the mechanistic studies are so important to try to only target the TGF - beta receptor signaling in the primary cilia but not in other parts of the body,» says Ogretmen.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

The structures of membrane - bound BCL - 2 proteins have been long sought - after because they hold the keys for understanding the mechanistic basis of activity and for the development of selective drugs free of off - target effects.

With the microRNA signatures of mitochondrial function and dysfunction in RPE cells in hand, combined with a detailed mechanistic understanding of how these microRNAs are transferred from cell to cell, we can use small interfering RNAs to target specific microRNAs and block their adverse effects on mitochondria function and their transfer to other RPE cells.

The mechanistic complexity of the cascades will be explained using the examples of crucial Cdk1 targets including Sic1, the Cdk1 target and inhibitor controlling the G1 / S transition in budding yeast, and Far1, the molecule defining the decision between mating and entry into cell division.

Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

We are interested in the mechanistic function and structure of antimicrobial / antifungal proteins and peptides and the identification of target molecules for the development of new antimicrobial / antifungal therapies.

Our research will contribute to a better mechanistic understanding of the microbes that live in our gut, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

mTOR is mammalian (or mechanistic) Target of Rapamycin.