Sentences with phrase «mechanistic understanding»

The authors conclude that this level of mechanistic understanding of external digestion in a modern animal may provide a window to understanding the early evolution of digestion and the systems controlling it.

Once we have a better mechanistic understanding of the factors that drive selective modulation of GABAB receptors, we can assess how these new compounds affect various behaviors in animal models.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

Schwietzke S., G. Pétron, S. Conley, C. Pickering,..., C. W. King, A. B. White, L. Bianco and R. C. Schnell (May 2017): Improved Mechanistic Understanding of Natural Gas Methane Emissions from Spatially Resolved Aircraft Measurements.

With the microRNA signatures of mitochondrial function and dysfunction in RPE cells in hand, combined with a detailed mechanistic understanding of how these microRNAs are transferred from cell to cell, we can use small interfering RNAs to target specific microRNAs and block their adverse effects on mitochondria function and their transfer to other RPE cells.

«This work provides the first demonstration of this combination of omics tools to gain a more mechanistic understanding of life in permafrost and the changes that occur during natural thaw,» said Jansson.

This novel knowledge management framework, which is already transforming the world of toxicology, has the potential to penetrate other fields such as biomedical research, where effective translation of mechanistic understanding into application is central to innovation and progress.

The resulting collaborations are crucial to advancing our knowledge of biology, including human health and disease; connecting model organism researchers and human biologists with one another speeds progress for both groups, facilitates mechanistic understanding of disease gene functions, and helps uncover novel disease mechanisms and candidate therapeutic targets.

Our goal is to gain mechanistic understanding how altered expression or function of key mitotic regulators (e.g. GTPases, kinases) can give rise to genetically unbalanced cells that may initiate tumorigenesis.

His theology — and natural theologies of the time like his — filled out the argument for the existence of God from design with mechanistic understandings of the universe.

«We continue to be fascinated by the functions of bacterial CRISPR systems and how mechanistic understanding leads to opportunities for new technologies,» said Doudna, a professor of molecular and cell biology and of chemistry and a Howard Hughes Medical Institute investigator.

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.

Implementation of Organ - on - Chips technology within the pharmaceutical industry aims to improve the probability of success of drugs by generating pre-clinical models that are more human - relevant and enable mechanistic understanding of human diseases and drug action.

Muscle fatigue has been described and studied in enormous detail for centuries but mechanistic understandings remain obscure.

This paper analyzes samples from a group of individuals that is more than twice as large as the original 2008 paper defining the effect of FKBP5, and adds mechanistic understanding: how regulation of the FKBP5 gene is perturbed.

«Future studies can provide mechanistic understanding by examining how specific compounds in coffee are involved in telomere maintenance.»

A limitation of the insights from the energy balance is that they do not provide a closed mechanistic understanding of what controls the ITCZ position.

The project that Alexey Amunts has been working on led to the most detailed mechanistic understanding of the molecular mechanisms underpinning the process of protein synthesis in human mitochondria.

«Now we have a much more mechanistic understanding the mediator behind this clinical presentation,» Dr. Dana said.

Our research will contribute to a better mechanistic understanding of the microbes that live in our gut, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

The individualistic, mechanistic understanding of psychology we can now see as flawed; our freedom is more socially or politically or Historically conditioned than our Founders thought.

For two reasons: it takes away the simple, mechanistic understanding that hard, physical, certain reality was the paradigm by which we must understand the world.

The major challenge is getting closer to a mechanistic understanding of why type 2 diabetes and obesity occur and why they have become so much more common in the last 40 - 50 years.

The findings that describe the structure and function of TMEM16A pave the way for a mechanistic understanding of this important family of membrane proteins, and they provide a promising template for developing drugs for the treatment of cystic fibrosis.

A mechanistic understanding of how diseases operate on the biochemical level offers one alternative.

«First it will provide a mechanistic understanding of how the bacterium causes disease in cotton, and second it provides a potential strategy for control of this cotton disease and resistance against the bacteria,» she said.

From the in vitro reconstituted Rad3 - Rad26 complex, small - angle X-ray scattering and electron microscopic studies, it is possible to model the quaternary structure and thus bring us closer to a mechanistic understanding Rad3 - Rad26 DNA repair apparatus.

Now that the pieces are being connected and the role of prostaglandin is established, Wingert will turn attention to gaining a deeper molecular and mechanistic understanding of how the molecule works in kidney development, especially the gene targets of the signaling.

A mechanistic understanding of bleaching is critical for developing strategies to mitigate or eliminate the problem of coral decline.

«A mechanistic understanding of how plants resist or overcome pathogen attack is crucial to develop new strategies for crop protection.»

Seeking to improve that mechanistic understanding, the UCSB researchers and colleagues from the Centre for Genomic Regulation (CRG) in Barcelona turned to the Catalan Institute of Nanoscience and Nanotechnology.

«Ultimately, the goal is to apply our models to arrive at a mechanistic understanding of the roles microbiota products may play in human physiology, and in turn, diagnose and treat disease,» said Lee.

But a mechanistic understanding of how the chemical topology of silica surfaces alter the structure of water at the surface could lead to a rationale design of these processes.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

Until now, a mechanistic understanding of how DNA methylation might influence the intrinsic membrane excitability of neurons, or IME, was lacking.

«We're looking for a mechanistic understanding of how body temperature rhythms are regulated.

The work, he says, «is really starting to give us some mechanistic understanding of the molecular basis of evolution.»

Whatever their origin, we need a much greater understanding of the brain before we will have a mechanistic understanding of the cause of these psychiatric disorders which will then guide us towards effective treatments.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

Also, through these studies we solidified the mechanistic understanding for how p53 functions in the cytosol, which complements its pro-apoptotic role in the nucleus.»

Our laboratory and many others have worked toward a detailed mechanistic understanding of some of the major features of Drosophila development.

One thing I learn at work, where hardly anything involves the mechanics discussed in this forum, is that «mechanistic understanding» is applicable to just about everything involving a scientist and his / her work.

The goals of his research are to obtain a mechanistic understanding of how cells interact both within our own bodies and with pathogens.