Sentences with phrase «mechanistic understanding by»

«Future studies can provide mechanistic understanding by examining how specific compounds in coffee are involved in telomere maintenance.»

Not exact matches

For two reasons: it takes away the simple, mechanistic understanding that hard, physical, certain reality was the paradigm by which we must understand the world.

Furthermore, interactions between the environment and the epigenome may provide mechanistic insight into many toxicological phenomena that are not well - understood, such as non-genotoxic carcinogenesis, age - based windows of susceptibility, developmental reprogramming by early life exposures, and trans - generational exposure effects.

«This is really the first time we've gone from risk variants highlighted by GWAS to a mechanistic and molecular understanding — right down to the nucleotide — of how a mutation can contribute to the risk of developing disease,» says Whitehead Founding Member Rudolf Jaenisch, who is also a professor of biology at MIT.

Sweeney found that the mechanistic answers that Pinker offered about the mind — the brain - based mechanisms of thought and consciousness being discovered by modern neuroscience — inspired her to replace her Catholic faith with science's empirical skepticism, which she finds, after many hilarious detours, «a much more powerful and reliable tool for understanding the world.»

«We continue to be fascinated by the functions of bacterial CRISPR systems and how mechanistic understanding leads to opportunities for new technologies,» said Doudna, a professor of molecular and cell biology and of chemistry and a Howard Hughes Medical Institute investigator.

My goal is to contribute to the resolution of this important problem by bringing to bear recent advances in human genetics and integrative genomics and translating them in a mechanistic, systems - level understanding of disease that is rooted in human biology but also actionable from a drug development perspective.

Using a mouse model, his work is beginning to elucidate a mechanistic understanding of a form of amyotrophic lateral sclerosis that is caused by protein misfolding.

I think that this investment has accelerated to the pace of research in the field of glaucoma; the number of publications that are really focusing on these mechanistic insights have just exploded in the last ten years, so this investment by Glaucoma Research Foundation was really a catalyst that allowed us to dig in deeper to understanding what's actually happening in the disease as the disease is progressing.

Dr. Cole's project, «Mechanistic Derivation of Germ Line Mutation by Genome - Wide Mouse Tetrad Analysis,» will help define the global patterns of de novo germ line mutations and the frequencies at which such mutations occur in mice, with the long term goal of understanding the molecular mechanisms underlying germ line mutagenesis and developing strategies to prevent or treat disorders caused by such mutations.

A recent scientific review by Nicole Templeman and colleagues (the Journal of Endocrinology) states that, «Genetic profiling studies could be used to understand the mechanistic underpinnings of this variation [individual responses to macronutrients].