«We continue to be fascinated by the functions of bacterial CRISPR systems and how
mechanistic understanding leads to opportunities for new technologies,» said Doudna, a professor of molecular and cell biology and of chemistry and a Howard Hughes Medical Institute investigator.
Our research will contribute to a better
mechanistic understanding of the microbes that live in our body,
leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.
We chose to highlight a diverse set of biological processes and experimental systems to make the point that the principles of cross species analysis of basic gene function extend to the study of all human disorders, and can
lead to
mechanistic understanding of disease pathogenesis and rationale for the development of new therapies.
Our research will contribute to a better
mechanistic understanding of the microbes that live in our gut,
leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.
The Guidance Note for
Lead Authors of the IPCC Fifth Assessment Report on Consistent Treatment of Uncertainties impose upon the lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g., mechanistic understanding, theory, data, models, expert judgment) and the degree of agreem
Lead Authors of the IPCC Fifth Assessment Report on Consistent Treatment of Uncertainties impose upon the
lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g., mechanistic understanding, theory, data, models, expert judgment) and the degree of agreem
lead authors to assign subjective levels of confidence to their findings: «The AR5 will rely on two metrics for communicating the degree of certainty in key findings: 1 Confidence in the validity of a finding, based on the type, amount, quality, and consistency of evidence (e.g.,
mechanistic understanding, theory, data, models, expert judgment) and the degree of agreement.