Sentences with phrase «mechanistic understanding of»

Schwietzke S., G. Pétron, S. Conley, C. Pickering,..., C. W. King, A. B. White, L. Bianco and R. C. Schnell (May 2017): Improved Mechanistic Understanding of Natural Gas Methane Emissions from Spatially Resolved Aircraft Measurements.

The research aims for mechanistic understanding of the processes important to the decadal modulation of ENSO and tropical Pacific decadal variability through model experiments and observational analysis.

Without a mechanistic understanding of coupling to regime states it seems impossible to quantitatively disentangle nonlinearity in the climate state.

A limitation of the insights from the energy balance is that they do not provide a closed mechanistic understanding of what controls the ITCZ position.

We lack a mechanistic understanding of how sparse populations of this small predator could be having a substantial impact on prey.

Our findings highlight gaps in our mechanistic understanding of how particular dietary characteristics alter energy balance, suggesting directions for future research regarding pathways involved in hunger, satiety, absorption, metabolism, and adipocyte growth or hyperplasia.

«We are seeing an explosion in our mechanistic understanding of how microbial communities in our intestines and elsewhere influence multiple aspects of immune and metabolic health,» said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology.

Despite its pervasiveness and severity, our mechanistic understanding of this maladaptive foraging behaviour is incomplete.

Our research will contribute to a better mechanistic understanding of the microbes that live in our gut, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

We chose to highlight a diverse set of biological processes and experimental systems to make the point that the principles of cross species analysis of basic gene function extend to the study of all human disorders, and can lead to mechanistic understanding of disease pathogenesis and rationale for the development of new therapies.

The results provide a valuable resource for future studies aimed at a mechanistic understanding of the function of O - GlcNAc on specific proteins during T cell activation.

Vertical integration is requisite to gain a mechanistic understanding of how genomic variation translates to phenotypes and fitness of organisms in their natural environment.

The goal of our conference is to disseminate recent findings emerging from cell biology, biochemistry, biophysics, functional - genomics, systems and computational approaches; and integrate them into a mechanistic understanding of the global principles of cell division.

In light of these realizations, the long - term scientific goal of the program is to develop a detailed and mechanistic understanding of not just the tumor cell and tumor mutations, but also all the components of the host microenvironment that influence cancer and the response to cancer therapy.

The overall aim of my research is to develop a mechanistic understanding of the pathogenesis of accelerated cardiac and renal dysfunction during cardio - renal syndrome.

This work is a critical step toward a mechanistic understanding of the nitrogenase enzyme.

The CNCR focuses on the mechanistic understanding of gene function in the context of cognitive function.

Towards a Mechanistic Understanding of Anaerobic Nitrate Dependent Iron Oxidation: Balancing Electron Uptake and Detoxification, Hans Karl Carlson, Iain Clark, Ryan Melnyk, John D. Coates, Frontiers in Microbiology, 3:57, doi: 10.3389 / fmicb.2012.00057, February 20, 2012.

Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Research in the Immunology, Microenvironment and Metastasis program is aimed at 1) merging basic mechanistic understanding of multidisciplinary pathways of host - tumor interactions and metastatic dissemination with novel translational opportunities for diseases diagnosis and immunotherapy, as well as 2) investigating mechanisms regulating immune responses in cancer and their potential therapeutic manipulation.

This work provided greater mechanistic understanding of airway remodeling that occurs as a result of viral exacerbation in respiratory diseases and an improved model for predicting the response to therapeutic candidates.

Once we have a better mechanistic understanding of the factors that drive selective modulation of GABAB receptors, we can assess how these new compounds affect various behaviors in animal models.

With the microRNA signatures of mitochondrial function and dysfunction in RPE cells in hand, combined with a detailed mechanistic understanding of how these microRNAs are transferred from cell to cell, we can use small interfering RNAs to target specific microRNAs and block their adverse effects on mitochondria function and their transfer to other RPE cells.

Using a mouse model, his work is beginning to elucidate a mechanistic understanding of a form of amyotrophic lateral sclerosis that is caused by protein misfolding.

Our laboratory and many others have worked toward a detailed mechanistic understanding of some of the major features of Drosophila development.

This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.

The work, he says, «is really starting to give us some mechanistic understanding of the molecular basis of evolution.»

«We're looking for a mechanistic understanding of how body temperature rhythms are regulated.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

Until now, a mechanistic understanding of how DNA methylation might influence the intrinsic membrane excitability of neurons, or IME, was lacking.

The researchers» findings contribute to the mechanistic understanding of how the machinery required to initiate and propagate action potentials of neurons are controlled at the level of alternative splicing — a very tiny piece of the neuronal maturation puzzle, but one that has a significant impact.

But a mechanistic understanding of how the chemical topology of silica surfaces alter the structure of water at the surface could lead to a rationale design of these processes.

«A mechanistic understanding of how plants resist or overcome pathogen attack is crucial to develop new strategies for crop protection.»

A mechanistic understanding of bleaching is critical for developing strategies to mitigate or eliminate the problem of coral decline.

Now that the pieces are being connected and the role of prostaglandin is established, Wingert will turn attention to gaining a deeper molecular and mechanistic understanding of how the molecule works in kidney development, especially the gene targets of the signaling.

A mechanistic understanding of how diseases operate on the biochemical level offers one alternative.

The major challenge is getting closer to a mechanistic understanding of why type 2 diabetes and obesity occur and why they have become so much more common in the last 40 - 50 years.

«This work provides the first demonstration of this combination of omics tools to gain a more mechanistic understanding of life in permafrost and the changes that occur during natural thaw,» said Jansson.

The individualistic, mechanistic understanding of psychology we can now see as flawed; our freedom is more socially or politically or Historically conditioned than our Founders thought.

Finally, insofar as a mechanistic understanding of nature and a pragmatic conception of truth are the correlates of the abstract individual and the liberal notion of freedom as power, even a Newtonian understanding of nature, reason, and freedom will eventually destroy the foundations for the rationality of natural law, as reason is reduced to the calculation of forces and law becomes an extrinsic imposition.

Not exact matches

Being mechanistic, modern science is also historicist: It argues that a complete description of the efficient and material causal history of an entity is a complete explanation of the entity itself» in other words, that an understanding of how something came to be is the same as understanding what it is.

Instead of a mechanistic view of the universe, the process - relational understanding is holistic and ecological, seeing the world as dynamic, creative, throbbing, pulsating with energy, interrelated and interdependent.

This abandonment of the intellectual task of understanding the world is as detrimental to society as was the mechanistic view that it partly replaced.

Buber's philosophy of dialogue has made possible a new understanding of the problem of evil because it has reaffirmed the basic significance of the personal relation between the Absolute, the world, and man as against the tendency to submerge man in a mechanistic universe or to reduce God to an impersonal and indirect first cause, an abstract monistic absolute, or an immanent vital force.

The Hebrew understanding of «the land» certainly implied relations to nature that are excluded in the mechanistic worldview.

But the understanding of the world in the Bible and in the Christian tradition prior to the Enlightenment is certainly organic rather than mechanistic.

Compared with organicistic and mechanistic metaphors, the root metaphor of artistic process is difficult to understand.

We can only hope that they find out that the mechanistic ritual of praying 5Xs per day, reciting verses that they do not understand (and indeed mean nothing), getting up at taxing hours of the morning and abstaining from food and water until the sunset are not means to becoming more spiritual, but are instruments to control their mind.

This is not because such words are supposed to have some kind of vitalistic tinge which will redeem what we have to say from apparent mechanistic suggestions, but because they are in fact required for any genuine understanding of the world and any sound explanation of how things come to be.

They remain so to this day, despite the enormous advances in our understanding of many of the processes from a mechanistic standpoint.