M Sergides, T Galgani, C Arbore, FS Pavone, M Capitanio, «An Optical Setup for the Study
of Mechanotransduction in Living Cells at the Single Molecule Level», Biophysical Journal 112 (3), 588a (2017)
The study dives
into mechanotransduction — how hair cells sense mechanical sound waves, or in this case, water waves, and convert them into brain signals.
McDermott's team discovered hair cells on the zebrafish skin use
different mechanotransduction genes — like tmc2b — depending on their orientation.
Only few material - based technologies exist today that enable the local control of receptor clustering and are able to
measure mechanotransduction - based cellular reactions.
David Krizaj, PhD Moran Eye Institute, University of Utah, Salt lake City, Utah Funding provided by Dr. James and Elizabeth Wise Project:
RGC Mechanotransduction as a Target in Glaucoma
The clinical study from OSUWMC proved that PrimaVie promoted skeletal muscle adaptation through upregulation of ECM - related genes that control
muscle mechanotransduction properties, elasticity, repair, and regeneration.
«We studied a zebrafish gene that is analogous to a human gene that causes deafness, and here we show the defect is in the process
of mechanotransduction.»
The study identifies tmc2b as central to
mechanotransduction.
Mechanotransduction The effects of extracellular matrix stiffening on endothelial cell health Cynthia Reinhart - King, Cornell University The effects of membrane cholesterol and extracellular matrix elasticity on vascular smooth muscle cell mechanics and migration Zhongkui Hong, University of South Dakota
We also have a strong interest in
mechanotransduction, i.e., how circulating cells transduce fluid shear forces into changes in biochemical signaling cascades.
Dr. Zuker is known for his work in sensory neuroscience, including mechanisms of phototransduction,
mechanotransduction, and more recently taste.
In December 2015, Marios joined the «Single Molecule Manipulation and Imaging» group at LENS where his current work is mainly focused on the concept of
mechanotransduction.