«
This medial septum GABA circuit works through the local PV interneurons in the hippocampus to instruct stem cells to become activated or to stay quiet,» Song said.
This is a confocal image showing a close association between
medial septum - to - hippocampus GABA projections and local PV interneurons in the hippocampus.
Song and her team found that in mice,
the medial septum - to - hippocampus circuit works to keep DG stem cells in this normal, low - activity state.
In the new study, Song and colleagues discovered that this hippocampal PV interneuron - signaling is regulated by a GABA circuit coming from
the medial septum, a cluster of neurons near the front of the brain.
She and her team now want to determine whether
the medial septum - to - hippocampus circuit can be targeted with therapies to protect DG stem cells and restore normal DG neurogenesis in cases where neurogenesis is abnormal.
There have been hints too that Alzheimer's specifically involves losses of
the medial septum neurons that connect to the hippocampus to control neurogenesis.
A major contribution came from a group of investigators working in Vienna, including Stumpf and Wolfgang Petsche, who established the critical role of
the medial septum in controlling hippocampal electrical activity, and worked out some of the pathways by which it exerts its influence.
«In previous studies, we found specific cells in
the medial septum that fire at higher rates when the mouse moves faster.
Not exact matches
These muscles are placed on top of orbital
septum and originate from a deep head linked to
medial palpebral ligament.