And researchers were truly surprised to find genes that produce proteins called adhesins and hemagglutinins, substances that
mediate cell invasion — and were previously found only in pathogens that attack animals.
Not exact matches
Their paper, «Id4 suppresses MMP2 -
mediated invasion of glioblastoma - derived
cells by direct inactivation of Twist1 function,» was recently published in Oncogene.
We are focusing on a few key molecular pathways including; 1) Polycomb -
mediated epigenetic gene silencing in the tumor initiation, maintenance, and
invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor
cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.
GPCRs and their downstream signaling are involved in cancer growth and development by controlling many features of tumorigenesis, including immune
cell -
mediated functions, proliferation,
invasion and survival at the secondary site.
Specifically, we will characterize the role of Clone 10 in red blood
cell invasion and schizogeny by performing immunolocalization studies on infected red blood
cells, and
invasion / growth inhibition assays to determine the role of anti-Clone 10 antibodies in
mediating resistance.
PRDM4
mediates YAP ‐ induced
cell invasion by activating leukocyte ‐ specific integrin β2 expression
Although it is formally possible that the LARP7 KD may also affect other yet - to - be-identified pathways in a P - TEFb - independent manner, our observation that both flavopiridol and siCDK9s efficiently rescued the increased
cell migration of LARP7 KD
cells lends a strong support to the notion that the observed effects of LARP7 KD on EMT and
invasion are indeed
mediated by P - TEFb activation.