Sentences with phrase «mediate cellular responses»

Hydrogen peroxide and other ROS mediate cellular responses in aging and myriad common chronic diseases, including diabetes, heart disease, stroke, cancer, and neurodegeneration.

Nanoparticle - mediated cellular response is size - dependent.

Not exact matches

A newly discovered stress response pathway relies on fat molecules to mediate cellular health.»

Dr. Coyle's group used the SR - / - mouse model to explore the role of glutamatergic transmission in the regulation of 5 - HT2AR - mediated cellular and behavioral responses.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Specifically, we aim to investigate how muscle - specific genetic interventions can regulate lifespan, the role of myokines in mediating the crosstalk between muscle and other tissues, and the cellular and molecular responses induced in distant tissues.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Although rejection can result from pure antibody - mediated rejection, more frequently rejection is part of a comprehensive immune response that includes some degree of cellular rejection.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

Important features of XMRV biology include (1) tropism for a variety of cell lines, including prostate cancer DU145 and LNCaP cells [27], [43], [48], and human neural cell types [57], (2) adaptations that promote growth in prostate epithelium and human - derived prostate cancer cell lines including an androgen response element in the promoter region [58] and downregulation of APOBEC3G [59], and (3) cellular effects with potential oncogenic properties including increased tumor aggressiveness mediated by downregulation of p27 [60] and differential regulation of several microRNAs [61].

(ii) the carbohydrates on the surface can serve as targeting molecules and trigger cellular uptake via specific receptors or mediate specific cellular responses [10].

102, 103 One proposed mechanism thought to mediate these effects is an up - regulation of cellular stress resistance in response to ER, which may occur via a process called hormesis.

PEITC shares the same - N = C = S reactive bit as sulforaphane from broccoli, and the much the same cellular mechanism (induction 100s of genes with the Antioxidant Response Element promoter, mediated by Keap1 - Nrf2).