With evidence that the intestines naturally
mediate their own
permeability by releasing zonulin from the
gut wall, researchers were finally able to gain a deeper understanding of what causes a leaky
gut.
In the case of gluten, zonulin -
mediated permeability affords
gut contents, including bacterial toxins, access to the bloodstream, where they can play a significant role in driving inflammation and associated psychiatric symptoms, as discussed here.