Key studies in mice showed that NF - κB can
mediate immune rejection of tumors.
Not exact matches
An adoptive transfer experiment was performed to confirm that the high incidence of corneal allograft
rejection was
immune -
mediated.
The precise
immune mechanisms that
mediate corneal graft
rejection remain poorly understood even after 50 years of research in laboratory animals.
The notion that CD4 + T cells might be the pivotal mediators of corneal graft
rejection arose from studies demonstrating the close correlation between delayed - type hypersensitivity (DTH), a classical CD4 + T cell -
mediated immune process, and corneal graft
rejection in rodents (10, 11).
These findings also demonstrate the remarkable plasticity and redundancy in the
immune mechanisms that
mediate allograft
rejection.
Although
rejection can result from pure antibody -
mediated rejection, more frequently
rejection is part of a comprehensive
immune response that includes some degree of cellular
rejection.
immune -
mediated skin diseases, autoimmune hemolytic anemia, thrombocytopenia, rheumatoid arthritis, inflammatory bowel disease, polyarthritis and more) Often used in combination with other drugs to suppress the
immune system Used to prevent organ
rejection post transplantation Not often prescribed to cats due to its toxicity What dogs / cats should not take this medication?