«This finding suggests that the pathophysiology of AMS may not only be dependent on arachidonic - acid pathway and inflammation triggered by ibuprofen, but also other mechanisms that
mediate nociception influenced by acetaminophen,» concluded Dr. Basnyat and his co-investigators.
Specific to pregnancy, these findings are consistent with earlier work linking childbirth - associated pain and catastrophizing with subsequent depressive symptoms.22 — 24 The association between pain and depression is complex and may be
mediated, in part, by differences in central
nociception pathways.