Sentences with phrase «mediated allograft»

«Long - term prevention of organ rejection: Biologists use immunoproteasome inhibition to prevent chronic antibody - mediated allograft rejection.»

These findings also demonstrate the remarkable plasticity and redundancy in the immune mechanisms that mediate allograft rejection.

Not exact matches

The capacity of CD8 − T cells from CD4 KO donors to mediate corneal allograft rejection is puzzling and on the surface, counterintuitive, since these cells are presumably double negative (DN) T cells.

An adoptive transfer experiment was performed to confirm that the high incidence of corneal allograft rejection was immune - mediated.

The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).

The capacity of CD8 + T cells to mediate corneal allograft rejection could have been due to the CTL population that might have been present in the CD8 + T cell suspensions used in the adoptive transfer inocula.

In their study, DN T cells displayed allospecific cytotoxicity in vitro and mediated tumor allograft rejection in vivo.

Both CD8 − and CD8 + T cells from CD4 KO corneal allograft rejector mice mediated corneal allograft rejection following adoptive transfer to nude mice.

However, some studies have demonstrated a role for CD8 + T cell - mediated rejection of skin and cardiac allografts (16, 17).

Until recently, the dogma in transplantation immunology held that allograft rejection was a Th1 CD4 + cell - mediated process.