Sentences with phrase «mediated by complex»

Given the strength of the Hurst coefficients — something we all agree on — is it not possible that a large portion of the current warming trend is a product of internal climate variability, as mediated by complex dynamics of ocean circulation?

His work engages the public domain, memory, and myth, and how these topics are mediated by complex social, economic, and urban landscapes.

Given the strength of the Hurst coefficients — something we all agree on — is it not possible that a large portion of the current warming trend is a product of internal climate variability, as mediated by complex dynamics of ocean circulation?

Not exact matches

However, it is difficult to conceive how the complex unity and integration of parts of a past experience can be mediated by the brain.

Specific to pregnancy, these findings are consistent with earlier work linking childbirth - associated pain and catastrophizing with subsequent depressive symptoms.22 — 24 The association between pain and depression is complex and may be mediated, in part, by differences in central nociception pathways.

Membrane trafficking within the Golgi complex is mediated by COPI (coat protein complex I)- coated vesicles.

Thus, the closed conformation of syntaxin - 1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE - complex / Munc18 -1 assemblies.

Their passage is mediated by specialized membrane complexes called translocases.

RNAi is mediated by RNA - induced silencing complex (RISC), which contains a small RNA and an Argonaute protein at its core and cleaves the target RNA.

The study showed that FL118 inhibits p53 polyubiquitination and monoubiquitination through the oncogenic Mdm2 - MdmX E3 complex, while stimulating Mdm2 - mediated MdmX ubiquitination — by changing the target specificity of Mdm2 - MdmX E3 complex from p53 to MdmX.

The new findings are the latest evidence that eating is a complex biological behavior mediated by multiple sites in the brain.

Studies of the complex chemical and biochemical interactions that occur at the interface between an aqueous phase and a living or nonliving surface provide insight into the chemical transformations mediated by microorganisms found on the surfaces of both living and artificial materials.

Efforts to study the molecular mechanisms that mediate these complex processes in different anatomical compartments have been impeded by difficulties in the isolation and propagation of endothelial cells from different organs.

Using a simulation model, the authors showed that these complex interactions between plants mediated by soil biota equalise growth differences between plant species, thus promoting their long - term coexistence.

The Raf ‐ 1 kinase inhibitor protein participates in the pathogenesis of IL ‐ 17 ‐ mediated autoimmune diseases and inflammation by promoting the formation of the IL ‐ 17RA ‐ Act1 complex, required for downstream signaling and cytokine production.

Homeotic function of Drosophila Bithorax - Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system.

Review of «The Effects of Platelet - Derived Growth Factor - BB on Human Dental Pulp Stem Cells Mediated Dentin - Pulp Complex Regeneration» from STEM CELLS Translational Medicine by Stuart P. Atkinson

BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA.

Also, many complex behaviors are mediated by distributed interacting networks.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Here, through a genome - wide CRISPR - Cas9 - mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing by the HUSH complex.

Silencing of the Oct4 promoter in P19 cells is a complex process, mediated by a combination of events including orphan receptor binding, DNA methylation, histone deacetylation, and heterochromatin formation [36], [37].

Their food related problems might reflect an adverse additive effect of multiple modest hypersensitivity reactions mediated, for instance, by immune complexes promoting autoimmune reactions in the joints.»

This food sensitivity testing method detects the delayed allergic response that is mediated by an IgG response and immune complexes.

This peptide can gain access to the gut - associated lymphoid tissue, is recognized by an enzyme called transglutaminase, and this complex stimulates a T - cell mediated immune response, perpetuating chronic inflammation and autoimmunity.

Food sensitivities that are more subtle and delayed are mediated by a different immune complex, Immunoglobulin G (IgG), and are referred to as delayed hypersensitivity reaction allergies.

Climate change awareness is complex and strongly mediated by socially constructed attitudes.

Given the multiple drivers of migration (Black et al., 2011a and b) and the complex interactions which mediate migratory decision - making by individual or households (Raleigh, 2008; McLeman and Smit, 2006; Kniveton et al., 2011; Black et al., 2011a and b), the projection of the effects of climate change on intra-rural and rural - to - urban migration remains a major challenge.

Mediated complex matter involving an alleged breach of joint venture agreement entered into by an American company engaged in the business of providing television programming in Latin America and an Argentine TV producer

He has also been certified to mediate Medical Malpractice Disputes by the statewide Medical Malpractice panel and the statewide panel for Complex Business and Technology disputes.

Judge Ahalt has successfully mediated tens of thousands disputes in areas including complex business transactions, construction, personal injury, medical malpractice, real estate, landlord and tenant, and contracts.He is frequently called upon by the parties and judges to mediate the most challenging judicial controversies involving post trial and appellate issues.

Drug - Induced Stevens — Johnson Syndrome (SJS) is an immune - complex - mediated hypersensitivity disorder caused by an adverse allergic reaction to medications.

For example: (1) relationships among different types of parent involvement; (2) the relative importance of different aspects of parent involvement at different points in the life of the student; and (3) the complex processes by which different types of involvement interact to mediate, moderate, or suppress each other.

Although less preferred, on occasion and in appropriate circumstances, we have mediated less complex cases or limited issues by video - conferencing or telephone conference alone.