Sentences with phrase «mediated by obesity»

Not exact matches

Research on baseline predictors of success in obesity treatment has consistently revealed that children from «obese families» (ie, with the presence of obesity in parents / siblings) show less weight reduction in the lifestyle intervention programs.9, — , 12 This association is possibly mediated by genetic factors.

Regarding the child, the importance of the intrauterine and early postnatal environments for metabolic programming and modifications of the epigenome is increasingly recognised, 12 — 14 particularly for metabolic diseases such as obesity and diabetes.15 Thus, GDM is related to macrosomia at birth (> 4 kg), to excess body fat and (central) obesity and to insulin secretion in infants and children, the obesity being in part mediated by maternal body mass index (BMI) or birth weight.16 — 23 Intrauterine exposure to GDM also doubles the risk for subsequent type 2 diabetes in offspring compared with offspring of mothers with a high genetic predisposition for type 2 diabetes, but with normal glucose tolerance during the index pregnancy.24 Maternal prepregnancy overweight and excessive gestational weight gain also predict high birth weight and adiposity during infancy.12 25 This is highly relevant, as up to 60 % — 70 % of women with GDM are overweight or obese before pregnancy.26 Finally, maternal lifestyle behaviour such as a high fat diet or lack of physical activity during pregnancy can influence offspring adiposity independent of maternal obesity.12 27

It remains to be shown whether the effect of low cognitive stimulation on childhood obesity is mediated by higher levels of TV viewing.

Low childhood SES and a harsh family environment were associated with elevated C - reactive protein, mediated in part by psychosocial resources and also by obesity; higher body mass index was a particularly significant predictor of elevated C - reactive protein.