Sentences with phrase «mediated by the genes»

Like free will, it is a process mediated by the genes but not caused by them.

Alternatively, oral teeth develop in a highly ordered sequence mediated by genes.

Not exact matches

«By either skipping a mutation region or precisely repairing a mutation in the gene, CRISPR - Cpf1 - mediated genome editing not only corrects Duchenne muscular dystrophy mutations but also improves muscle contractility and strength,» said co-author Dr. Rhonda Bassel - Duby, Professor of Molecular Biology and Associate Director of the Hamon Center for Regenerative Science and Medicine.

Small molecules called metabolites mediate a cell's survival, and metabolite production is fine - tuned by genes that indirectly sense metabolite levels.

The team first set out to determine which RBPs were critical in RNA - mediated gene regulation by applying an RNAi screen to mESCs.

Microglia are activated during Alzheimer's disease progression and may mediate an initially protective inflammatory response, a notion that is also supported by epidemiological studies linking mutations in the TREM2 gene to increased risk of Alzheimer's and other neurodegenerative diseases.

These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones.

The protein encoded by the PIK3C2G gene belongs to the phosphatidylinositol -4,5-bisphosphonate 3 - kinase (PI3K) family, which plays a critical role in cancer.28 Experimental evidence suggests that activation of PI3K signaling enhances production of COX - 2 and PGE2, which results in inhibition of apoptosis in colon cancer cell lines that can be restored with NSAID - mediated blockade of PI3K.29

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

A new strategy for functional signaling studies of B ‐ cell lines by the CRISPR / Cas9 mediated deletion of BCR and B ‐ cell co ‐ receptor genes.

Gene induction pathways mediated by distinct IRFs during viral infection.

The symposium features presentations by Philippa Marrack and John Kappler talking on the T cell repertoire; William Paul on interleukin 4 as a prototypic immunoregulatory cytokine; Timothy Springer on lymphocyte trafficking; Pamela Bjorkman on structural studies of MHC and MHC - related proteins, and Jack Strominger on peptide presentation by class I and II MHC proteins; Thierry Boon on genes coding for tumor rejection antigens, including the first tumor antigen, MAGE - 1; and Philip Greenberg on the modification of T cells for adoptive therapy by retroviral - mediated gene insertion Since then, the symposia series has attracted leading immunologists in the cancer vaccine and antibody fields, providing them with a comprehensive view of the promises and challenges in the development of cancer immunotherapies.

His academic research focused on gene regulation and signal transduction mediated by ion channels and G proteins.

A study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate T cell proliferation, gene expression, cell adhesion and migration 44.

Augmentation of adenovirus 5 vector - mediated gene transduction under physiological pH conditions by a chitosan / NaHCO3 solution.

Concerns about immunological consequences of rAAV - mediated gene transfer were substantiated by the outcome of a clinical trial in which human hemophilia B patients were infused into the liver with rAAV -2-F.

Programmable nucleases, ZFN, TALEN and RGENs enable gene knockout in cultured cells and organisms by producing site - specific DNA double - strand breaks, whose repair via error - prone non-homologous end joining (NHEJ) or microhomology - mediated end joining (MMEJ) gives rise to frameshift mutations.

The degree of phenotypic correction of murine ß — thalassemia intermedia following lentiviral - mediated transfer of a human γ — globin gene is influenced by chromosomal position effects and vector copy number.

Clock genes mediate the antiproliferative function of sympathetic signaling by inhibiting G1 cyclin expression.

These GEMM - ESCs, with often multiple modified alleles, form the basis for further genetic engineering either by Flp - recombinase mediated integration, gene targeting or Crispr / Cas9 to allow for the evaluation of altered target gene expression in a spontaneous tumor model.

By studying the expression of these genes, the neurons that mediate learning have been identified.

Homeotic function of Drosophila Bithorax - Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system.

Systemic acquired resistance is induced by R gene - mediated responses independent of cell death

Understanding molecular mechanisms underlying tumor suppression mediated by the RB1 and TP53 genes

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].

Resistance gene N - mediated de novo synthesis and activation of a tobacco mitogen - activated protein kinase by tobacco mosaic virus infection

This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon - alpha

Centromeres associate with dispersed gene loci, and these gene contacts are mediated by condensin.

Background: Small non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free - living and parasitic lineages of flatworms, but only few key factors of the small RNA pathways have been exhaustively investigated in a limited number of species.

Here, through a genome - wide CRISPR - Cas9 - mediated forward genetic screen, we identified MORC2 as an essential gene required for epigenetic silencing by the HUSH complex.

We have generated new genetic tools for the analysis of in vivo mast cell functions that allow for cell type - specific inactivation («knock out «-RRB- of target genes selectively in mast cells by Cre loxP - mediated recombination.

Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.

One - step generation of mice carrying mutations in multiple genes by CRISPR / Cas - mediated genome engineering.

The effect of management on pathogens appears to be mediated by immunity, with feral bees expressing immune genes at nearly twice the levels of managed bees following an immune challenge.

Identification and Characterization of Plant Genes Involved in Agrobacterium - Mediated Plant Transformation by Virus - Induced Gene Silencing

PEITC shares the same - N = C = S reactive bit as sulforaphane from broccoli, and the much the same cellular mechanism (induction 100s of genes with the Antioxidant Response Element promoter, mediated by Keap1 - Nrf2).

Receptor molecules coded by the 7 - repeat allele have been found to have a lower potency for dopamine - mediated coupling to adenylate cyclase than receptors encoded by the other frequent, 2 - or 4 - repeat forms [90], and more recent results suggest an additional effect of the 48 bp VNTR on gene expression [91, 92].

The transcription factor nerve growth factor - inducible protein a mediates epigenetic programming: Altering epigenetic marks by immediate - early genes