Sentences with phrase «mediated by the immune system»

Boehringer Ingelheim is actively involved in research related to such conditions as cardiovascular, metabolic and respiratory diseases, cancer, AIDS, hepatitis C, and diseases mediated by the immune system.

As this regulation mechanism mediated by the immune system also plays an important role in other diseases such as leukemia, these findings could lead to novel therapeutic approaches.

These include genome instability / mutation, which they discussed previously, and tumor - promoting inflammation, mediated by immune system cells that are recruited to the site of a developing tumor.

CD is an allergic reaction to gluten that is mediated by the immune system by T - cell activation in the gastrointestinal mucosa.

Some adverse food reactions are mediated by the immune system (true allergy) whereas others are not (food intolerance).

Blood testing for allergies measures levels of immunoglobulin E (Ig E) and is not accurate for food allergies or sensitivities because not all allergic reactions are mediated by IgE, nor or all food reactions mediated by the immune system.

Not exact matches

Most notably, immune - mediated diseases are expected to be significantly influenced by such reagents as epigenetic changes have been widely noted to influence the immune system.

Both tasocitinib and Incyte's drug, INCB028050, target Janus kinases, which mediate signaling by immune - system proteins called cytokines.

S. mansoni IPSE binds to Immunoglobulin E (IgE), an antibody produced by the immune system that is expressed on the surface of basophils, a type of immune cell; and mast cells, another immune cell that mediates inflammation; and sequesters chemokines, signaling proteins that alert white cells to infection sites.

Multiple sclerosis (MS) affects about 2.3 million people worldwide and is thought to be caused by an immune system - mediated attack on the body.

Stimulation of the insect immune system by Wolbachia is one of the proposed mechanisms explaining Wolbachia - mediated antiviral protection in mosquitoes [29], [30], [32], [35].

Stephen Alexander, UK - Cannabinoid receptors, transporters, endocannabinoid turnover, hydrogen sulphide turnover Arthur Christopoulos, Australia (GPCRs Liaison)- G protein - coupled receptors; analytical pharmacology; allosteric modulation; biased agonism; drug discovery; neuropharmacology John Cidlowski, USA (NHRs Liaison)- Glucocorticoid receptor signaling; apoptosis and the immune system Anthony P. Davenport, UK (Chair Evolving Pharmacology, GPCRs Liaison) Doriano Fabbro, Switzerland - Kinases and their biology, kinase inhibitors, drug discovery, pharmacology of drugs (kinase inhibitors) in the indication oncology, biology of oncology Kozo Kaibuchi, Japan Yoshikatsu Kanai, Japan - Transporters, amino acid signals, epithelial function, cancer biology Francesca Levi - Schaffer, Israel - eosinophils and mast cells as effector cells in allergic inflammation: characterization of new receptors / ligands, hypoxia / angiogenesis and eosinophils, asthma, atopic dermatitis, allergic rhinitis, immunopharmacological modulation of allergic diseases by bispecific recombinant antibodies, bacteria interactions with eosinophils and mast cells, the allergic effector unit, mast cell derived tumors: new antibody based treatment, the allergic inflammation and the resolvome, non IgE - mediated mast cell activation in diseases Eliot H. Ohlstein, USA (Editor)- Drug discovery and development, urogenital biology, cardiovascular / metabolic medicine John A. Peters, UK (LGICs Liaison) Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Joerg Striessnig, Austria (VGICs Liaison)- Physiology, pharmacology and pathophysiological role of voltage-gated calcium channels

These antibodies are mediated by the IgG branch of the immune system (different branch than the one that makes food allergies)- this is known as a Type IV Delayed Hypersensitivity reaction.

The immune system reacts to unknown / novel compounds through the innate system, which is mediated by white blood cells including macrophages and dendritic cells, complement cascades, natural killer cells, and cytokines.

However, this terminology is a misnomer and suggests that only IgE allergies exist and that reactions mediated by different parts of the immune system are non-existent.

Food allergies are mediated by the IgE part of the immune system, take effect immediately and are often called a «True Allergy» by medical professionals.

It just so happens that keeping us happy by mediating immune responses and tight junction function, helping identify harmful intruders, and producing short chain fatty acids like butyrate puts the flora in good standing with our immune systems.

More recent research describes adenosine as «a mediator with multisystemic effects», and it is produced by almost all cells, playing a role in heart function, sleep, bone health, activation of the immune system and mediating the effect of various hormones.

However, this terminology is a misnomer, and suggests that only IgE allergies exist, and that reactions mediated by different parts of the immune system are nonexistent.

Food allergies are mediated by the IgE part of the immune system, take effect immediately and are often called «True Allergies» by medical professionals.

Among the more common include: breed predisposition (inherited), immune mediated disorders (caused by the animal's own immune system), use of certain drugs, and some systemic diseases.

Most cases are considered «immune - mediated» and result from attack by the animal's own immune system on their own tear - producing glands.

The researchers, led by Dr Steven Holloway from the University of Melbourne Faculty of Veterinary Science, have taken DNA from 100 dogs in the quest to determine what in their genetic makeup causes diseases such as diabetes, granulomatous meningitis (similar to multiple sclerosis) and immune - mediated haemolytic anemia, a condition which causes the immune system to attack red blood cells.

This inflammation can be caused by infection of the brain (bacterial, viral, fungal and parasites are examples of infectious causes of encephalitis) or can be immune - mediated; which means the body's immune system is malfunctioning and creating abnormal inflammation for reasons we do not fully understand.

A rare illness in Beagles is the immune mediated polygenic arthritis, a condition whose symptoms are explained by the fact that the dog's immune system attacks the joint, and this may occur even at an early age.

Cell mediated immunity is directed by cells of the immune system, primarily helper T cells that activate in response to an antigen presented by an invading microbe.

It is considered to be an immune - mediated condition, which means that the inflammation is triggered by some allergic or over-active response of the cat's own immune system.

ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C & S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb's anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection, diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)