Sentences with phrase «mediated cell cycle»
Among the multiple p53 transcriptional targets, p21 stands out as the main, although not exclusive, effector of p53 - mediated cell cycle arrest (8, 9, 10).
http://cancerres.aacrjournals.org/ Not exact matches
The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF receptor - induced phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.
The cell cycle regulator p21 mediates the ability of the tumor suppressor p53 to arrest cellular proliferation.
Altogether, these findings highlight the central role of Lkb1 during neural crest cell lineage and uncovered a link between Lkb1 - mediated pyruvate - alanine cycling and glial commitment.
In support of the relevant role of p21 in mediating p53 - dependent cell - cycle arrest, cells derived from p21 - null mice arrest proliferation inefficiently after p53 activation (8, 9, 10).
Specifically, my research proposal addresses the mechanisms by which the kinase 3 - phosphoinoside dependent protein kinase - 1 (PDK1) mediates resistance to cell cycle related CDK4 / 6 inhibition in ER + breast cancer and explores the in vivo effects of inhibiting PDK1 in combination with CDK4 / 6 inhibitors toward ER + breast cancer growth.
González - Sarrías, A.; Ma, H.; Edmonds, M.E.; Seeram, N.P. Maple polyphenols, ginnalins A-C, induce S - and G2 / M - cell cycle arrest in colon and breast cancer cells mediated by decreasing cyclins A and D1 levels.