Sentences with phrase «mediated cell killing»

AAV2 mediated cell killing of multiple breast cancer cell lines representing both low and high grades of cancer and targeted the cancer cells independent of hormone or growth factor classification.

Not exact matches

Their study, the researchers say «establishes a role for cell wall - associated GAG in mediating resistance to killing of Aspergillus by NETs and provides the first example of a virulence factor of A. fumigatus that is able to mediate enhanced virulence when expressed in a less pathogenic Aspergillus species».

Simultaneously, a cell - mediated immunity system also becomes active, deploying cytotoxic T - cells to directly recognize and kill pathogen - infected cells.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

Virologists have long known that HIV infects and kills CD4 + T cells, which mediate the body's immune response to viruses.

«Immune checkpoint inhibitors amplify T - cell responses and are currently being tested in the clinic to increase T - cell - mediated tumor killing,» says Pedro Lowenstein, M.D., Ph.D., co-senior author.

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.

Trastuzumab directly inhibits the proliferation of HER2 - overexpressing breast cancer cells and induces immune - mediated killing of target cancer cells through antibody - dependent cellular cytotoxicity [20].

Likely one reason for this is the generation of butyrate, which has been studied for its ability to kill colorectal cancer cells and mediate tumor growth.

The numerous flavonoids found in astragalus appear to enhance cell - mediated immunity by increasing the number of T - helper cell type 2 cytokines, increasing levels of tumor necrosis factor and interleukin - 6, which stimulates the activity of macrophages, responsible for killing potentially harmful cells.

Autoimmune hemolytic anemia — also called immune - mediated hemolytic anemia, IMHA and AIHA - is a common, sometimes manageable but potentially fatal disease where a dog's red blood cells (RBCs) are killed prematurely.