Sentences with phrase «mediated cellular protein»

This study reveals how lipids control SH2 domain - mediated cellular protein interaction networks and suggests a new strategy for the therapeutic modulation of pY - signaling pathways.

Not exact matches

Through a series of protein - mediated signals, mTORC1 interprets cues in the cellular environment, including nutrient availability, and instructs the organism to react accordingly.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

Enabled by the chemistry provided by Nate Jui in the Buchwald lab at MIT, Tardiff found that the compound was working by restoring functions mediated by a cellular protein critical for trafficking that was previously thought to be «undruggable.»

At the cellular level, p53 can either induce senescence or, of major interest here, inhibit senescence by controlling both reactive oxygen species (ROS) levels and a signaling pathway mediated by protein kinases AMPK and mammalian target of rapamycin (mTOR).

Our reasoning, admittedly speculative, is that (a) the cancer cellular phenotype is a wayward phenotype characterized by reduced intercellular cooperation, cooperation that is largely mediated through glycoproteins, proteoglycans, and glycosylated proteins; (b) cells evolve the cancer phenotype in part by disabling the enzymes which glycosylate proteins; (c) therefore (the speculative inference) dietary steps which downregulate glycosylation may inadvertently serve to entrench or promote the cancer phenotype.

His doctoral research focused on the structure and function of ion channels, the proteins that mediate cellular electrical properties.