Stephane completed his PhD at Cold Spring Harbor Laboratory studying RNA interference
mediated gene regulation in Robert Martienssen's Lab.
The team first set out to determine which RBPs were critical in RNA -
mediated gene regulation by applying an RNAi screen to mESCs.
Not exact matches
The Lazar lab has been working on HDAC3 for over a decade, focusing on the pivotal role of this enzyme in hormone -
mediated regulation of
gene expression and metabolism.
Furthermore, if transcriptional
regulation of adipose tissue function contributes to adiposity - dependent modulation of insulin sensitivity, blood pressure, and other medically important traits, then the
genes that correlate with body mass will be candidates for
mediating these responses and warrant further evaluation.
Prolactin -
mediated regulation of lipid biosynthesis
genes in vivo in the lactating mammary epithelial cell.
His academic research focused on
gene regulation and signal transduction
mediated by ion channels and G proteins.
Researchers find Nrf2, a stress response
gene, to be a pluripotency
gene which
mediates its effects through
regulation of the proteasome
Thus, clock
genes may
mediate the leptin - dependent sympathetic
regulation of bone formation.
With her recent groundbreaking findings in the field of RNA -
mediated regulation based on the CRISPR - Cas9 system, E. Charpentier has laid the foundation for the development of a novel, highly versatile and specific genome editing technology that is revolutionizing life sciences research and could open up whole new opportunities in biomedical
gene therapies.
268/4: 45 Identifying the transcription factors
mediating enhancer — target
gene regulation in the human genome.
Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1 - dependent
gene regulation and IFN --LCB- gamma -RCB--
mediated host defenses
Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of
gene expression
regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.
More recently, it has been suggested that the contrasting attributes of
gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin
mediated regulation for maintaining distinct expression patterns in the
gene sets [29].