Sentences with phrase «mediated gene transfer»

«The data from this study show the promise of vector - mediated gene transfer as an approach for immunization,» says Pat Fast, chief medical officer at the International AIDS Vaccine Initiative.

Other often utilized technologies are fluorescence activated cell sorting, tissue culture, gene expression analysis, protein analysis, and lentiviral mediated gene transfer.

Therapeutic levels of fetal hemoglobin in erythroid progeny of -LCB- beta -RCB-- thalassemic CD34 + cells following lentiviral vector - mediated gene transfer.

High level erythroid lineage - directed gene expression using globin gene regulatory elements following lentiviral vector mediated gene transfer into primitive human and murine hematopoietic cells.

Adenovirus - associated virus vector - mediated gene transfer in hemophilia B. N Engl J Med 365 (25): 2357 - 65, 2011.

Concerns about immunological consequences of rAAV - mediated gene transfer were substantiated by the outcome of a clinical trial in which human hemophilia B patients were infused into the liver with rAAV -2-F.

Viral - mediated gene transfer now enables investigators to overexpress or knock out a gene of interest within highly localized regions of brain.

Not exact matches

She identified that specific killing of myeloid cells represents an additional mechanism of suppression mediated by Tr1 cells, and she contributed to the definition of a new protocol for Tr1 cell induction using IL - 10 gene transfer and in the discovery of the biomarkers of Tr1 cells.

Persistence of non-viral vector mediated RPE65 expression: Case for viability as a gene transfer therapy for RPE - based diseases.

Manno, Catherine et al. «AAV - Mediated Factor IX Gene Transfer to Skeletal Muscle in Patients with Severe Hemophilia B.» Blood.

The degree of phenotypic correction of murine ß — thalassemia intermedia following lentiviral - mediated transfer of a human γ — globin gene is influenced by chromosomal position effects and vector copy number.

AAV gene therapy vectors are emerging as the gene transfer vehicle with high potential for use in the CNS as they transduce post mitotic cells that mediate the sustained, long term gene expression required in chronic progressive diseases.

This study will combine direct tumor cell killing (TK) and immune - mediated stimulatory (Flt3L) gene transfer approaches delivered by first generation adenoviral vectors.

Background: Horizontal transfer of mobile genetic elements (MGEs) that carry virulence and antimicrobial resistance genes mediates the evolution of methicillin - resistant Staphylococcus aureus, and the emergence of new MRSA clones.

1) Plant - mediated gene silencing: Using plant - mediated gene silencing, scientists induce plants to transfer pieces of genetic material to other organisms, targeting and interfering with the interactions between plants and their pests at the genetic level.