Sentences with phrase «mediated immune responses»

We have also discovered an adapter molecule called Act1 that has an important role in regulating autoimmunity through its impact on both T - and B - cell - mediated immune responses.

In addition, Dr. Webb has been studying new vaccine strategies to induce T cell - mediated immune responses.

Chemokine - mediated immune responses in the female genital tract mucosa.

Thus MSC interact and suppress cell - mediated immune responses directly and through soluble factors.

Boosting cultures are frequently used to maximize the in vitro detection of cell - mediated immune responses that are initially induced in vivo (28).

«The development of DNA - based vaccines with cytokine adjuvants has emerged as particularly promising for inducing antiviral and anti-tumor, cell - mediated immune responses.»

Beta - carotene has been found to reduce cell damage caused by free radicals, and improves immune function by enhancing cell mediated immune responses.

The research, published online May 26 by Nature Immunology, shows that GATA - 3 is required for the maintenance and function of CD8 + T - cells, a T - cell type mediating the immune response to clear pathogens, eradicate tumors and promote inflammation.

They not only exist in many different varieties, but also perform a wide range of functions, ranging from intracellular communication and the transport of substances into or out of the cell to mediating the immune response.

Short term T - cell mediated immune response blockade promotes the functionality of hESC - derivative grafts in immune - competent mice.

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

Similar to these projects, IDRI's subunit tuberculosis vaccine, ID93, also utilizes adjuvants that induce a cell - mediated immune response, which is required for protection against M. tuberculosis infection in low dose aerosol models of TB.

Your depression is caused by an interferon - gamma mediated immune response in the brain, probably caused by a viral or bacterial infection.

It just so happens that keeping us happy by mediating immune responses and tight junction function, helping identify harmful intruders, and producing short chain fatty acids like butyrate puts the flora in good standing with our immune systems.

However, if your friend does not actually have true food allergies and is instead experiencing an IGG - mediated immune response to commonly eaten foods (eggs, dairy, shellfish, nuts, corn, wheat), eliminating those foods from the diet can resolve any health issues she was experiencing as a result of having this type of immune response.

TSLP is no ordinary compound, it is an interleukin - 7 cytokine that is capable of creating a powerful Th2 mediated immune response.

This peptide can gain access to the gut - associated lymphoid tissue, is recognized by an enzyme called transglutaminase, and this complex stimulates a T - cell mediated immune response, perpetuating chronic inflammation and autoimmunity.

It mediates the immune response by enhancing the production of virus - fighting interferon and promoting the function of phagocytes, which engulf and destroy foreign pathogens.

[1] When we consider the available evidence base, we have to zoom out to appreciate its inherent limitations — antibody - mediated immune response is just one mechanism by which the body can be alerted to a perceived threat.

A food sensitivity is an IgG - mediated immune response that may be associated with unwanted symptoms such as bloating, abdominal pain and headaches — just to name a few.

If the above links aren't enough to pique your interest, depression is associated with systemic inflammation and a cell - mediated immune response.

MetaStim, the common name for the SP (squalane, Pluronic ®) oil adjuvant, is an emulsion used in vaccines to help elicit a humoral and cell - mediated immune response.

Not exact matches

It is scientifically plausible that our entire hypothalamic - pituatary - adrenal (HPA) axis, which mediates long - term stress responses and immune function, as well as short - term fight - or - flight reaction, is permanently mis - set by the continuing high stress hormone levels that ensue when newborn babies are routinely separated from their mothers.

Olefsky concludes that TLR4 mediates the immune system's response to fat.

Researchers uncovered the following pathway: gut bacteria stimulate intestinal B lymphocytes to release interleukin (IL)-10 that, in turn, induces development of regulatory T lymphocytes that prevent excessive inflammatory responses and limit immune - mediated disease.

The finding that immune cells in the skin, especially skin showing an autoimmune response, mediate the strongest anti-tumor response is surprising because T cells are traditionally thought to reside in immune organs, such as lymph nodes, spleen, and blood.

Dr. Quintana's research is focused on the regulation of the adaptive and innate immune response and the identification of biomarkers for multiple sclerosis (MS) and other immune - mediated diseases.

Virologists have long known that HIV infects and kills CD4 + T cells, which mediate the body's immune response to viruses.

«First, the effect of cortisone is mediated by macrophages which usually serve as scavenger cells in an immune response.

Even though STAT3 activity drives the expansion of MDSCs and is involved in immune responses mediated by the cells, they found that high levels of STAT3 activity actually prevent the differentiation of MDSCs to macrophages.

Several reports indicated that B cells can mediate immune suppression and negatively affect the antitumor immune response in several cancer types.

CRI Investigator Gabriel Rabinovich and his team identify a novel strategy mediated by secretion of the sugar - binding protein galectin - 1 that is used by tumors to escape the immune response.

Investigating conventional MHC - restricted T cell responses specific for tumor - associated peptide antigens, and local immune contextures, in mediating cancer control in patients following neoadjuvant (per - surgery) therapy.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Directed transport of neutrophil - derived extracellular vesicles enables platelet - mediated innate immune response.

TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium.

The hallmark of an effective T cell response is the formation of a stable long - lived population of cells that mediate immune memory.

The lab is characterizing the quantity and quality (i.e. B and T cell) of the immune responses induced or generated by these DNA plasmids in order to improve their ability to mediate virus neutralization and clearance.

INTERPRETATION: We have developed a gene gun mediated Abeta42 gene vaccination method that is efficient to break host Abeta42 tolerance without using adjuvant and induces a Th2 immune response.

We're seeing a lot of these patients with very impressive immune - mediated responses, even with advanced disease.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.

NIMML researchers employ advanced computational tools in combination with experimental and clinical studies to capture variation and diversity of immune responses, and develop safer, more - effective precision medicine treatments for infectious and immune - mediated diseases.

There, they will be exposed to tumor antigens released from dying glioma cells through TK + valacyclovir - induced glioma cell death, and thus mediate a specific anti-malignant glioma immune response against remaining malignant glioma cells.

Although rejection can result from pure antibody - mediated rejection, more frequently rejection is part of a comprehensive immune response that includes some degree of cellular rejection.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

The group focuses on endogenous mechanisms that control (i.e. limit) immune responses in vivo and thereby prevent inflammatory disease caused by immune - mediated damage to host tissues.

The fact that responses occurred in the presence of high levels of anti-CVA21 antibody and in the absence of circulating infectious CVA21 supports an immune - mediated response as opposed to one caused by the virus entering the tumor.

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.