Sentences with phrase «mediated signal transduction»

Our finding that Gasp constitutively associated with Grb2 is quite intriguing and provides some possible links to hypothesize its function in positive selection, because Grb2 is an important adaptor for Sos in the TCR - mediated signal transduction pathway.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Sethna F, Zhang M, Kaphzan H, Klann E, Autio D, Cox CL, Wang H. (2016) Calmodulin activity regulates group I metabotropic glutamate receptor - mediated signal transduction and synaptic depression.

Additionally, most of the cancer cell lines expressing olfactory receptors express the effectors necessary for OR - mediated signal transduction.

Felder et al. «Anandamide, An Endogenous Cannabimimetic Eicosanoid, Binds to the Cloned Human Cannabinoid Receptor and Stimulates Receptor - Mediated Signal Transduction», Proc.

Plant HK components are involved in hormonal and possibly light - mediated signal transduction processes, hence it is difficult to eliminate their input in our system.

The current project will use high - resolution mass spectrometry - based metabolomics approaches to measure temporal and spatial changes of metabolic pathways in the RPE and retina under both physiological and disease conditions, with a focus on mTOR - mediated signal transduction pathways.

Murat completed his PhD at NCSU focusing on systems biology of growth factor - mediated signal transduction pathways.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

His graduate and postdoctoral work led to seven first author papers in the Journal of Biological Chemistry, including four back - to - back papers on fundamental characterization of arachidonic acid pathways, and a Cell paper, which was the first to demonstrate cAMP - independent G protein participation in receptor - mediated signal transduction.

Not exact matches

The actin cytoskeleton mediates these responses, but the signal transduction pathway leading to chloroplast movement and the mechanism of chloroplast motility is not entirely understood.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

His academic research focused on gene regulation and signal transduction mediated by ion channels and G proteins.

Phosphotransfer - mediated signaling pathways, involved in signal transduction, have been identified in Pseudomonas as the two - component GacS / GacA global regulatory system (39).

We have identified three classes of signal transduction mechanisms that may be mediated or modulated by NG2.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

Increased expression of transcription factor ATF2 — which is required for the amino acid depletion responses of genes such as ATF3, CHOP, SARS and 4EBP - 1 — is mediated by a signal transduction pathway that appears to involve an amino acid sensing GPR [37].