Sentences with phrase «mediated signaling cascade»
Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.
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TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.
Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen - activated protein kinase signaling cascades.
In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).
BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.
Multiple compounds with the Super DMZ 5.0 formula have been clinically demonstrated to activate / inhibit key signaling cascades involved in the regulation of blood glucose, glycogen synthesis, fatty acid synthesis, transcriptional regulation, and cytokine - mediated inflammation.