In four trials, clonidine was compared to a dummy treatment or no treatment, while six trials compared the drug with
the medication midazolam and in one trial, with fentanyl.
Prescription of pain relieving
medications including narcotics (hydro and oxycodone), anti-anxiety drugs (clomipramine,
midazolam, alprazolam), anti-inflammatories (aspirin and Tylenol like drugs), certain anti-depressants and nerve modulating drugs is now routine care for most patients.