Taken together, these data suggest that indole derivatives, although their IC50 values are in the micromolar range, represent functional leads for further development of novel CXCR4 antagonists useful in
medicinal chemistry programs.
Hits identified from a first iteration screen can be fed into
a medicinal chemistry program or converted into new baits (Bait B, center left in Figure) and used in a second iteration screen to identify more potent molecules.
Not exact matches
Sumit Chanda, Ph.D., professor and director of the Immunity and Pathogenesis
Program at Sanford Burnham Prebys Medical Discovery Institute (SBP), and Anthony Pinkerton, Ph.D., director of
medicinal chemistry at SBP's Conrad Prebys Center for Chemical Genomics, are collaborators on the effort.
deCODE and its partner in this
program, Roche, have initiated
medicinal chemistry work on compounds they have identified as active against targets in the PDE4D pathway.
Subsequently, I enrolled in the master
program in organic and
medicinal chemistry at the University of Gothenburg.
Michel Detheux, iTeos» Chief Executive Officer added, «The progress of our adenosine A2A antagonist
program demonstrates how we can rapidly apply our expertise in
medicinal chemistry, tumor immunology and translational medicine to advance candidates toward clinical development.»
Renowned Chemist Joins Scripps Florida - William R. Roush has been named professor of
chemistry, executive director of
medicinal chemistry, and associate dean of Florida graduate
programs.
As a graduate student, she was a member of the Interdisciplinary
Program of Drug Discovery, where she gained vital exposure to the multidisciplinary fields of
medicinal chemistry, pharmacology, and chemical biology.