Sentences with phrase «medicinal chemists»

McDonald is working with medicinal chemists at Vanderbilt to develop more selective and potent PGD inhibitors for testing in animal models, with the ultimate goal of moving these inhibitors into clinical trials for pancreatic cancer patients.

Saltiel is also working with medicinal chemists at the university to develop a new compound based on the drug that would optimize its formula.

«Having fewer steps and simpler chemical ingredients, as our method does, has potential benefits both for the pharmaceutical industry and for patients,» said Ge, the organic and medicinal chemist who developed the method and is the corresponding author of the Nature Chemistry study.

It could also make it far easier for medicinal chemists to tweak the genes to produce new versions of the drugs that might have fewer side effects and addictive properties.

Her group is also collaborating with a team of medicinal chemists to look for compounds that target only the alpha version of the retinoic acid receptor.

Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity.

After 14 years in the United States, as a student and as a scientist at a big pharmaceutical company, medicinal chemist Kamil Paruch (pictured at top) decided to return to his native Czech Republic.

If we can have a small positive influence in making medicinal chemists lives easier, that will be a success for us,» says Baran.

Once the cells are in place, «the gel provides a natural - like environment in which the cells sort themselves out,» says University of Utah medicinal chemist Glenn Prestwich, who invented the formula.

To make a compound work better against a specific disease target, medicinal chemists optimize the drug, tweaking its structure or physical properties to make it more effective and safer.

But, says Michael Varney, head of the small molecule drug discovery group at Genentech, those hiring trends are about to change: «For us, over the next 3 years, we'll hire more medicinal chemists and more process and scale - up chemists than we will analytical chemists.»

While Xi turned to a new receptor, another group of scientists, led by Sharkey and Northeastern University medicinal chemist Alexandros Makriyannis, developed a compound that targets the same spot as rimonabant, CB1, but features certain key differences that could overcome its flaws.

This development could find broad applications in pharmaceutical and agricultural industries, enabling medicinal chemists to tailor synthetic molecules with halogen substituents in order to improve their pharmacological profiles.

The researchers went a step further by demonstrating the utility of the product by performing nine different elaborations commonly used by medicinal chemists in drug development.

In practice, this means that when medicinal chemists discover a promising kinase inhibitor that exists as two interchanging arrangements, they actually have two different inhibitors.

«When you try to get medicinal chemists to look at Coot, it just doesn't work,» says Emsley.

The diverse set of antagonists described in this article will be useful in guiding medicinal chemists to rationally design effective CXCR4 antagonists for the treatment of human diseases where SDF - 1 / CXCR4 axis plays a critical role.

Crystal structures and other biochemical and genetic studies provide medicinal chemists like Buolomwini with the information they need to know which proteins the compounds target and to see how a drug binds to a them.

Many other experts also point out an ongoing need for medicinal chemists.

Dr. Soumen Paul has worked with medicinal chemists to design analogues of a compound capable of inhibiting protein kinase c lambda / iota.

«Our management team consists mostly of medicinal chemists, and this helps us to enter customers» labs at an early stage,» Dong says.

I'm a medicinal chemist who works at a major pharmaceutical company a few blocks away from Fenway Park.

I am a medicinal chemist at the University of Kentucky.

That's true of Rana Sanyal, 37, an organic and medicinal chemist.

As an intern at Smith Kline and French in Philadelphia, Pennsylvania, Bowen was a medicinal chemist, charged with finding a more selective agonist — an active binding agent — to be used in a spray to treat asthmatics.

For medicinal chemists, making tweaks to peptide structures is key to developing new drug candidates.

He found a perfect partner more than 5000 kilometers away near Utrecht, the Netherlands: Bastiaan Venhuis, a medicinal chemist who was also analyzing supplement ingredients.

As well as analytical and computational chemists, the company, with a work force of over 10,000, looks for synthetic organic chemists, medicinal chemists, and combinatorial chemists to join their research teams.

Many of the chemists hired by Sigma - Aldrich are medicinal chemists, but the company has a particular challenge recruiting analytical chemists.

Lee is not concerned; his colleague Michael Jung, a medicinal chemist at U.C.L.A., had tinkered with the original compound and found a series of variations that are 100-fold more potent.

Flippin reflects that thinking when he reels off FibroGen's list of needed specialists: medicinal chemists, bioanalytical experts, cell biologists, enzyme biologists, in vivo pharmacologists, and molecular biologists.

«This looks like a good approach,» says Bimal Banik, a medicinal chemist at the University of Texas Pan American, in Edinburg.

«Eventually all those [NSAID] molecules on the market will become dinosaurs,» predicts Philip Portoghese, a medicinal chemist at the University of Minnesota in Minneapolis.

Last year, for example, researchers led by Amy Hauck Newman, a medicinal chemist at the National Institute on Drug Abuse in Baltimore, Maryland, reported in Neuropharmacology that two of the group's newer D3R blockers, CAB2 - 015 and BAK4 - 5,4 appeared highly stable and potent.

«For chemists, there is a huge need across the board — medicinal chemists, organic chemists, formulation chemists, and so on,» says French.

Some chronic opioid users switch to kratom to wean themselves off of pain pills and ease withdrawal symptoms, says Oliver Grundmann, a medicinal chemist at the University of Florida in Gainesville.

Scientists have been searching for a drug that kills pain as successfully as opioids without the side effects for close to a hundred years, with no luck, says Sam Ananthan, a medicinal chemist at Southern Research in Birmingham, Ala..

By tweaking the yeast pathways, medicinal chemists may be able to produce more effective, less addictive versions of opiate painkillers.

The new work is «provocative,» says Scott Singleton, a medicinal chemist at the University of North Carolina.

However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day - to - day decisions.

This caused Yousef Al - Abed, a medicinal chemist at the Institute for Medical Research of the North Shore - Long Island Jewish Health System in Manhasset, New York,, and colleagues to wonder about MIF's role in another autoimmune condition, Type 1 diabetes.

ResMed, now entering its 32nd year, is a week - long graduate - level course providing an accelerated program for medicinal chemists, biologists and other industrial and academic scientists who wish to broaden their knowledge of drug discovery and development.

While the long - term toxicity and off - target effects of early stage candidate drugs need to be fully characterized, the development of safe and orally active CXCR4 antagonists is a major goal for medicinal chemists.

Harding, a medicinal chemist, and Wright, a neuroscientist, have been working on their compound since 1992, when they started looking at the impact of the peptide angiotensin IV on the hippocampus, a brain region involved in spatial learning and short - term memory.

Also, from 1982 — 1987, he was a medicinal chemist at Merck.

Joshua is an organic / medicinal chemist with many years of experience in small - molecule drug discovery.

Current work focuses on identifying novel Eph receptor - targeting agents (such as peptides and small molecules) as well as improving the existing ones in collaboration with medicinal chemists and structural biologists, and evaluating them in cell culture and in vivo animal models.