To address key questions of meiotic ploidy reduction, we screen for and characterise novel meiotic proteins, focusing on proteins that are specifically involved in
meiotic chromosome segregation and chromosome dynamics in mice.
An increase in the frequency of
meiotic chromosome segregation defects is a key factor underlying the decline in female fertility during aging.
Not exact matches
Members of the kinesin superfamily of motor proteins are essential for mitotic and
meiotic spindle organization,
chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule - based transport.
Meiotic prophase regulation and achiasmate
chromosome segregation in Caenorhabditis elegans.
Besides ensuring correct
chromosome segregation during the first
meiotic division, crossovers create new allele combinations in gametes, thereby increasing genomic diversity, increasing the chance of creating offsprings with better phenotypic fitness, and providing the basis for faster evolution.
11:00 AM Human «MeioMaps»: Genome - wide
meiotic recombination and
chromosome segregation outcomes in individual human oocytes.
One pivotal aspect of
meiotic chromosome biology and
meiotic ploidy reduction is the
segregation of homologous
chromosomes during the first
meiotic division.