Not exact matches
Used together, these products offer antioxidant protection, gentle controlled exfoliation, interruption of communication between
melanocytes and
keratinocytes, as well as inhibiting the production of excess melanin.
Inindividuals with albinism, genetic alterations interfere with the
melanocytes» production of pigment or their ability to distribute it to
keratinocytes, the major cell type of the skin's outer layer.
Wei Long Ng explained: «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as
keratinocytes and
melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.
To make the pigmented skin constructs, the team used three different types of skin cells —
keratinocytes,
melanocytes, and fibroblasts — and a two - step «drop on demand» bioprinting method.
The surgery is known as
melanocyte -
keratinocyte transplantation or MKTP.
After they're formed,
melanocytes migrate to the bottom of the hair follicle, where they give off a person's characteristic hair color to
keratinocytes that make up a hair.
Genodermatoses are characterized by genetic disorders of the skin affecting mainly either
keratinocytes or
melanocytes the two majors cell types of the epidermis.
Unlimited source of
keratinocytes and
melanocytes derived from pluripotent stem cell for epidermis cell therapy
In parallel, the generation of functional
melanocytes from pluripotent stem cells, capable of producing melanosomes and transferring them to
keratinocytes, will facilitate in vitro analysis of molecular mechanisms underlying melanocytic defects observed in genetic diseases such as neurofibromatosis or albinism.
Homogenous and functional population of
keratinocytes and
melanocytes derived from pluripotent stem cells were generated by designing a multi-step sequential protocol respecting the chronobiology of epidermis formation during human ontogenesis.
Ng explains, «The two - step bioprinting strategy involves the fabrication of hierarchical porous collagen - based structures (that closely resembles the skin's dermal region), and deposition of epidermal cells such as
keratinocytes and
melanocytes at pre-defined positions on top of the biomimetic dermal skin constructs, to create 3D in - vitro pigmented human skin constructs.
According to the Indian Journal of Dermatology, stress can have a most negative affect on the normal functioning of the
melanocytes and the
keratinocytes in the skin.
Melanin produced by
melanocytes, is stored within melanosomes and is transferred to
keratinocytes by a process known as cytocrinia (the same process by which melanin is transferred, in a normal epidermis, from
melanocytes to keratocytes).