Colocalization of inflammatory response with B7 - h1 expression in human
melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Also called congenital
melanocytic naevi these can be visible at birth and appear brown in fair - skinned babies or almost black in dark - skinned babies.
In parallel, the generation of functional melanocytes from pluripotent stem cells, capable of producing melanosomes and transferring them to keratinocytes, will facilitate in vitro analysis of molecular mechanisms
underlying melanocytic defects observed in genetic diseases such as neurofibromatosis or albinism.
My main area of expertise
include melanocytic lesions, adnexal tumors, cutaneous lymphomas and cutaneous inflammatory disorders.
«In addition, the results of this study provide new mechanisms for how abnormal pigmentation associated with
some melanocytic nevi and melanomas might arise as a result of immune responses to the growths.»
The availability of human pluripotent stem cells committed to
the melanocytic lineage in vitro, at all stages of differentiation, will be used to decipher the mechanisms that guide developmental processes.
While I still have moments of fear, having
a melanocytic lesion helped me get in touch with myself.