Sentences with word «memantine»

Traynelis reports that his clinical colleagues are developing guidelines for physicians on the use of memantine for children with GRIN gene mutations.

«One surprise was that many proteins that increased in level with normal learning also increased, although not as much, with treatment with memantine alone,» says Gardiner.

In 2003, the FDA approved memantine for moderate - to - severe Alzheimer's disease, but two years later the agency rejected an application from the manufacturer, Forest Laboratories, to expand the approval to mild Alzheimer's.

Patients with mild Alzheimer's who took memantine showed no improvement in mental function and their ability to handle everyday tasks (such as bathing and dressing) compared to those who took placebo, either within any one trial or when all of the data was combined.

CONCLUSION: These results extend previous findings that demonstrated the efficacy and safety of memantine in the treatment of patients with moderate to severe Alzheimer disease.

Therefore, researchers had been investigating a drug called memantine, currently FDA - approved for treating moderate to severe Alzheimer's disease, as a potentially promising therapy for treatment - resistant depression.

A trial of low - dose memantine in HD patients is currently being planned, so we should soon know whether it's safe to take, and whether it lives up to its promises in mice.

However, recent clinical data suggest that memantine does not exert rapid antidepressant action for reasons that are poorly understood.

It also includes experiments on whether drugs now used for Alzheimer's disease, such as memantine, could be repurposed to have beneficial effects for patients with certain mutations.

But if a patient has a history of stomach problems, he sometimes starts them on memantine first.

They have used memantine to show that a delicate balance is at the heart of the protection observed in HD mice.

The mice used in all these the studies were treated with memantine from a very young age, and we don't know what would happen if the mice received it only after they got sick - which is how most human patients are treated.

At low doses, though, memantine blocked only the bad class of NMDA channels, because they are physically easier for the drug to get to.

After being prescribed Aricept and later Memantine, which stops the destruction of brain messengers responsible for memory and learning, Jennifer found she could «hold a proper conversation again» and begin to regain control of her life.

The different effects of ketamine and memantine alter signals emanating from NMDA receptors, in particular those that determine antidepressant efficacy.

Memantine acts on the same receptors in the brain as fast - acting ketamine, said Dr. Lisa Monteggia, Professor of Neuroscience.

Traynelis and Yuan previously collaborated with the NIH's Undiagnosed Disease Program to show that the Alzheimer's medication memantine can be repurposed as an anticonvulsant, for a child with intractable epilepsy coming from a mutation in the GRIN2A gene.

«Memantine induces responses in a substantial number of proteins that we measured, and it does this without impairing or enhancing learning.

Gardiner's group used proteins arrays to see how protein expression changed in the brains of mice that underwent context fear conditioning and were given memantine compared with control mice.

The channels blocked by memantine are called «N - Methyl - D - Aspartate» or NMDA receptors.

In fact, the only serious problems in the study were reported in those who were given the pharmaceutical memantine.

Patients taking memantine continued to experience mental decline while on the drug, but less so than patients taking a placebo.

Pairing memantine with a cholinesterase inhibitor, a type of drug that prevents the breakdown of neurotransmitters involved in memory, has become a standard treatment for mild Alzheimer's disease, but this study «clearly flies in the face» of that approach, says William Thies, PhD, the chief medical and scientific officer of the Alzheimer's Association, a research and advocacy organization based in Chicago.

Dr. Jicha said memantine is usually added after patients have dosed up to recommended levels of donepezil (Aricept), rivastigmine (Exelon) or galantamine (Razadyne).

The company has the right to receive royalty payments from the sales of Namenda (memantine HCL), an approved drug marketed for Alzheimer's disease, and potential milestone and royalty payments from the development of XERECEPT, an investigational drug which has completed a Phase 3 clinical trial for the treatment of swelling associated with cerebral tumors.

The investigators gave the mice a drug called memantine, which is used to treat moderate to severe cases of Alzheimer's disease.

However, memantine doesn't work on all activating mutations, and could have effects on the unmutated NMDA receptors in the brain as well.

Some HD patients are already taking memantine, with or without the support of their physicians.

Those mice were unsuccessful with context fear conditioning, but they did as well as wild - type mice when they were treated with memantine.

Included in the ruling was the decision to restrict another drug, memantine, to people with moderately severe to severe forms of Alzheimer's.

«Although, both ketamine and memantine have similar actions when nerve cells are active, under resting conditions, memantine is less effective in blocking nerve cell communication compared to ketamine, This fundamental difference in their action could explain why memantine has not been effective as a rapid antidepressant» said Dr. Monteggia, who holds the Ginny and John Eulich Professorship in Autism Spectrum Disorders.

Everitt notes that while the drugs used in the current study are experimental, there are several drugs approved by the U.S. Food and Drug Administration that target the same receptors: Dextramethorphan, which is found in many over-the-counter cough suppressants and memantine, a drug approved to slow the progression of Alzheimer's disease, are examples.

Interestingly, it has recently been shown that memantine, an uncompetitive NMDA receptor antagonist that inhibits overactivity of NMDARs, was able to prevent retinal ganglion cell degeneration in streptozotocin - induced diabetic rats [73].

Memantine is an NMDA receptor antagonist, aimed at counteracting the overactivation of the receptor caused by the mutation.

Memantine has also been used to treat children with epilepsy associated with mutations in the related GRIN2D gene.

Memantine (Namenda) tends to improve functional and neuropsychiatric symptoms in patients with Alzheimer's disease more than it improves memory.

In addition to treatment with cholinesterase inhibitors, we also recommend treatment with memantine (Namenda) in patients with moderate and severe Alzheimer's disease, and in some cases, mild AD, who we believe would benefit.

A number of promising drugs for Alzheimer's have, for instance, worked in mice, but when they reach clinical trials with humans «an astonishing 99 % of them fail, and it has been 15 years since the last treatment, memantine, was approved,» she says.

They finished their study by showing that memantine, which blocks these channels, caused HD mice to show some improvement.

The drug, called Memantine, works by blocking specific channels in neurons (brain cells).

New research in HD mice suggests that low doses of memantine might be best, and hopefully a planned trial of low - dose memantine in HD patients will give us the answer.