Sentences with phrase «membrane of human cells»

The protein LecA on the surface of the bacteria binds to sugar on special lipid molecules, so - called Gb3 lipids, which are present in the outer membrane of human cells.

The liposomes fuse with the membranes of human cells, discharging the plasmid into the interior.

Not exact matches

Such whole - grain varieties contain high levels of phenols and tannins, two plant compounds with a knack for mopping up free radicals that can wreak havoc on cell membranes and other delicate machinery within the human body.

Lindsey Van Haute of the Free University of Brussels (VUB) in Belgium and colleagues spread human embryonic stem cells onto a porous membrane.

A membrane — designed to support the cultivation and differentiation of human nasal epithelial stem cells — was inserted into a small chamber on the device and fresh or contaminated air was fed through a tiny channel.

Last June Ingber's team reported that it had placed human lung lining cells and human capillary cells on either side of a porous, flexible polymer membrane.

«This technology gives us a new tool to examine membrane proteins in their natural environment of the human cell,» said Igor Stagljar, a Professor in the Donnelly Centre for Cellular and Biomolecular Research.

When added to human blood, the CP molecules stuck to the PC - groups on blood cell membranes because of their opposite charges.

The researchers concluded that using collagen - based membranes in organ - on - a-chip devices enhance the growth, viability and barrier function of human colon cells and that the method likely could be extended to cells from other organs.

In the past decade, scientists have watched protein and RNA molecules condensing into droplets, or membrane - free condensates, in many kinds of cells, from bacterial to human.

This image shows autophagic vesicles containing mutant K - Ras formed in the membrane of human pancreatic cancer cells after exposure to neratinib.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

The researchers created the nanosponges by separating the membranes of human red blood cells from their internal contents and stabilizing the membranes with an engineered core designed to absorb the toxins produced by pathogenic bacteria.

The OXA - dependent integration of inner membrane proteins, which has been conserved throughout evolution, is thus fundamental for the formation of the mitochondrial inner membrane and for the energy supply of human cells.

ATP is transported through further barrel pores across the mitochondrial outer membrane into the cytosol, which fuels life of human cells.

The epithelium's maturation into a villus intestinal epithelium with long finger - like extensions was helped along by co-culturing human intestinal microvascular endothelial cells on the opposite side of the shared matrix - coated porous membrane in the «vascular» channel where they assembled a surrogate blood vessel with a hollow lumen through which feeding medium was flowed.

In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which cells from a human intestinal cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human blood vessel - derived endothelial cells in the adjacent channel.

This report of the successful connection of capillaries with the podocytes of iPS cell - manufactured human glomeruli resulting in a distinct filtration membrane is the first of its kind in the world.

According to Cheeseman, this phenomenon takes place in virtually every plate of dividing human cells, yet no one else has taken note that in a quarter of those cells, the cell membrane grows only to one side in order to correct a potentially disastrous situation.

Whereas in the nematode experiment the researchers targeted nanoparticles to temperature - sensitive ion channels that naturally exist in the membranes of the worms» nerve cells, the scientists inserted the gene for a heat - activated ion channel called TRPV1 into the human and rat cells.

Römer and Eierhoff found evidence of the new mechanism in synthetic membranes as well as in cultures of human lung cells.

Our technological expertise ranges from the most fundamental approaches to study membrane transport in lymphocytes and dendritic cells (subcellular compartmentalization, intravital microscopy, phagosomal functions), the systematic analysis of gene expression and it regulation (RNAseq, Chip Seq, proteomics) and physiological and pathological immune responses (mouse models for cancer immunity, immunomodulation / vaccination, human clinical studies in cancer).

To illuminate the mechanisms behind this observation, they treated macrophages from both mice and humans with dimethyl itaconate, which is a version of itaconate that makes it easier to permeate through the cells» membrane.

Membrane topology of human presenilin - 1 in SK - N - SH cells determined by fluorescence correlation spectroscopy and fluorescent energy transfer.

Cytoskeletal rearrangements in human red blood cells induced by snake venoms: light microscopy of shapes and NMR studies of membrane function.

Organ - on - a-chip technology may in part overcome this limitation, as exemplified by the «breathing» lung - on - a-chip that recapitulates the alveolar - capillary interface by co-culturing human alveolar epithelial cells and capillary endothelial cells on opposite sides of a flexible, porous, ECM - coated membrane.

Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane.

Human amniotic membrane (AM), the innermost layer of the placenta is the most common substrate used for both in vitro cultures and as a vehicle for transfer of cells during transplantation, due to its structural similarities to the ocular surface, as well as its biological and functional properties.

When HIV enters the human body, it typically does so by clinging to only a handful of cells attached to a mucous membrane such as those in the genitals or rectum.

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

«The molecule weakens the cell membranes of bacteria, but human cells also have membranes,» said William Wuest, an associate professor of chemistry and a member of the Emory Antibiotic Resistance Center.

Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression.

(E) Rhodopsin - positive material (red) is present within the cell membrane of human specific marker (HSM)- labelled iPS - RPE (green) 8 days post-transplantation and in the tips of the host outer segment (OS) layer.

Cellular Component: Limbal epithelial cells Matrix Component: Basement membrane of HAM It is a 4 cm2 denuded human amniotic membrane with cultured autologous limbal biopsy explants with 80 % of the cells positive for p63 marker.

We suggest correct identification of the origin of these cells (using human specific markers, which define cell membranes) is essential in order to distinguish viable donor cells from host inflammatory cells which have engulfed transplanted cells.

Primary kidney epithelial cells isolated from human proximal tubule are cultured on the upper surface of an extracellular matrix - coated, porous, polyester membrane that splits the main channel of the device into two adjacent channels, thereby creating an apical «luminal» channel and a basal «interstitial» space.

Epidemiological evidence and intervention studies clearly show that in humans saturated fat significantly worsen insulin - resistance, while monounsaturated and polyunsaturated fatty acids improve it through modifications in the composition of cell membranes which reflect at least in part dietary fat composition.

And research appears to bear this out — in a laboratory study of human intestinal cells published in Cell Biology and Toxicology, the team concluded that mercury can alter cell membrane permeabilCell Biology and Toxicology, the team concluded that mercury can alter cell membrane permeabilcell membrane permeability.

Sulfur enables the transport of oxygen across cell membranes and not only is oxygen needed for healthy cellular regeneration in humans, it is the lack of oxygen that helps cancer cells to grow.

First, the cycle of Oxandrolone makes possible to strengthen protein synthesis; secondly, Anavar increases the level of human growth hormone; third, it blocks cortisol receptors in the membranes of muscle cells; in the fourth, it increases the concentration of creatine phosphate.

Immunity One cup of spinach contains over 337 % of the RDA of vitamin A that not only protects and strengthens «entry points» into the human body, such as mucous membranes, respiratory, urinary and intestinal tracts, but is also a key component of lymphocytes (or white blood cells) that fight infection.

I think it's interesting to note that human breast milk is full of saturated fat, the human liver makes saturated fat from carbohydrate, human body fat is roughly 40 - 50 % saturated, and our cell membranes are about half saturated fats.

The test addresses the following areas: - difference between living and nonliving things - semipermeable membrane - the sequence of increasing or decreasing levels of organization of the human body - the cell theory - Hooke and Leeuwenhoek - four common structures found in all cells - prokaryotic vs. eukaryotic cells - functions and structure of microscopes - cell organelles - difference between plant and animal cells - procedure for making a wet - mounted slide

Published articles address a broad range of subjects relating to the kidney and urinary tract, and may involve human or animal models, individual cell types, and isolated membrane systems.