An international group of researchers led by Professor Christoph Hess from the Department of Biomedicine at the University of Basel and University Hospital Basel have now found a structure that accounts for the rapid immunologic memory of particular immune cells (CD8 + memory T cells): these important
memory cells form multiple connections between mitochondria — the powerhouses of cells — and the endoplasmic reticulum, the site of protein production.
With every infection or vaccination,
memory cells form that the body uses to remember the pathogen.
«But this is a promising first step in understanding the mechanisms by which
memory cells form, which ultimately will play a role in improving vaccine efficacy.
Not exact matches
Neural stem
cells with the ability to
form new neurons in the brain are normally present in the hippocampus (the part of the brain connected to learning and
memory) and in the subventricular zone of the brain.
Disruptions to the ability of developing brain
cells to
form branching connections with other
cells, using a specific microRNA — miR - 9, was associated with an increase in the strength of fear - related
memories in adulthood.
Although amyloid clogs the brain early on,
memory loss tracks much better with a different protein, tau, which
forms so - called «tangles» within nerve
cells.
NEW ROLE A kind of brain
cell called an astrocyte (shown) may help nerve
cells in the hippocampus
form traumatic
memories, a study in rats suggests.
Study casts doubt on whether adult brain's
memory -
forming region makes new
cells.
WASHINGTON, D.C. — Helper
cells in the brain just got tagged with a new job —
forming traumatic
memories.
Scientists have long suspected that Alzheimer's patients lose their
memories and their wits when amyloid beta proteins
form needlelike aggregates that punch holes in brain
cells and kill them.
It is not clear whether all of the T
cell clones that respond to the initial infection have the potential to
form memory T
cells.
When T
cells respond to a pathogen, they proliferate, and a fraction of their progeny goes on to
form long - lived
memory cells.
A protein that can switch shapes and accumulate inside brain
cells helps fruit flies
form and retrieve
memories, a new study finds.
New research at Rice University suggests actin filaments that control the shape of neuron
cells may also be the key to the molecular machinery that
forms and stores long - term
memories.
Thirty days later, however, when the protein had been cleared from their bodies, the animals»
memory troubles were gone as well, and the number of newly
formed brain
cells was back to normal.
It could be, for example, that fluctuations in calcium levels in plant
cells leave imprints of stress in a way that's similar to how long - term
memories are
formed in animals.
This latter finding is of particular interest, says Christian Doeller of Radboud University Nijmegen in the Netherlands, and might support the idea that humans have a wider network of grid
cells that we use to help
form memories.
By repeating the experiment over and over, however, they are assembling a picture of what types of
cells exist, how those
cells function during tasks of place
memory, and what kinds of connections they
form with other
cells.
Depending on the person, particular
cells in the medial temporal lobe — an area critical to
forming long - term
memories — get fired up only by, for example, images of
Given that lot of those brain
cells seemed to
form down in the area of the hippocampus, which is involved with the
memory and with learning, it was an easy jump to naturally assume that they must be involved with that in some way.
It quickly became apparent that most of the
cells in the skin's outermost layer, the epithelium, don't stick around long enough to
form such
memories.
Strontium cobaltites are just one example of a class of materials known as transition metal oxides, which is considered promising for a variety of applications including electrodes in fuel
cells, membranes that allow oxygen to pass through for gas separation, and electronic devices such as memristors — a
form of nonvolatile, ultrafast, and energy - efficient
memory device.
This distributed biological
memory leverages the large number of
cells in bacterial cultures and encodes information into their collective genomic DNA in the
form of the fraction of
cells that carry specific mutations.
Changes in DNA methylation in brain
cells has been an extremely active research area since these epigenetic changes were shown to alter the expression of genes needed to
form and maintain long - term
memories.
The scientists believe that intercalated
cells form «extinction
memories,» which associate something previously feared (such as an air raid siren or a car backfiring) with a harmless outcome.
Building on their previous work that identified and activated
memory cells, a group led by RIKEN Brain Science Institute and RIKEN - MIT Center Director Susumu Tonegawa has now shown that spines — small knobs on brain -
cell dendrites through which synaptic connections are
formed — are essential for
memory retrieval in these AD mice.
Using a video game in which people navigate through a virtual town delivering objects to specific locations, a team of neuroscientists from the University of Pennsylvania and Freiburg University has discovered how brain
cells that encode spatial information
form «geotags» for specific
memories and are activated immediately before those
memories are recalled.
Buried deep underneath the folds of the cerebral cortex, neural stem
cells in the hippocampus continue to generate new neurons, inciting a struggle between new and old as the new attempts to gain a foothold in
memory -
forming center of the brain.
Instead, he proposes that
memories are stored in the specific pattern of connections
formed between engram
cell ensembles.
These CRISPR sequences act as a
form of genomic
memory that can be accessed to defend the
cell when it is invaded by plasmids or phages that contain the recorded sequences.
«Since cholesterol is required by neurons to
form synapses (connections) with other
cells, this decrease in cholesterol could affect how nerves function for appetite regulation, behavior,
memory and even pain and motor activity,» says Dr. Kahn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.
Professor Martin's research focuses on the
cell biology of transcription - dependent
forms of synaptic plasticity, particularly those underlying learning and
memory.
When the researchers modeled the effects in mice, they found it strengthened the connections between neurons that make learning possible — what is known as synaptic plasticity — by increasing the action of a
cell receptor critical to
forming memories.
Cortical
cells had
formed memories of the foot shock almost right away, well ahead of the anticipated schedule.
The grid -
cell model is striking not just for its elegance, but also because (as Edvard Moser notes) it
forms a key link between perception and
memory.
The CBM now
forms the core of the new Kavli Institute at Trondheim, which was inaugurated in August 2007 and where research continues on grid
cells, as well as areas such as understanding the role of the hippocampus in shaping
memory.
Researchers have discovered a new
form of synaptic plasticity, the changes to nerve
cells in the brain that underlie learning and
memory.
The big challenge previous allergy researchers faced was that immune
cells, known as T -
cells, tended to develop a
form of «
memory» so that once someone developed an immune response to an allergen, it would easily recur upon future contact.
The researchers studied the hippocampus, taking a closer look at the newly
formed brain
cells and the state of blood vessels in the region of the brain that plays an important role in emotions, spatial navigation, and
memory.
The
memory - boosting chemical was singled out from among 100,000 chemicals screened at the Small Molecule Discovery Center at UCSF for their potential to perturb a protective biochemical pathway within
cells that is activated when
cells are unable to keep up with the need to fold proteins into their working
forms.
This is often enough to halt the infection but the second part of the immune response is adaptive immunity, when dendritic
cells activate T lymphocytes and trigger a cascade of immune reactions, such as the formation of antibodies and killer
cells that clear the infection from the body and
form a
memory of the invading pathogen.
In recent years the importance of a number of different
memory B
cell subsets that can be
formed in response to vaccination or infection has started to become clear.
In a study published in the journal Neuron, researchers at the Gladstone Institutes reveal how tau disrupts the ability of brain
cells to strengthen connections with other brain
cells, preventing new
memories from
forming.
Electronic
memory boosters stem from research on the brain's ability to change and adapt over time by generating new brain
cells and
forming new neural pathways.
One of Frankland's own studies in mice, for example, found that as new brain
cells are
formed in the hippocampus — a region of the brain associated with learning new things — those new connections overwrite old
memories and make them harder to access.
The theory behind vaccination is based on these
memory cells: injecting a controllable
form of an infection to build a «
memory» towards a future attack.
Since cod liver oil contains the most concentrated
form of natural Vitamin A of any food as well as the special
form of Vitamin A named 14 hydroxy retro - retinol, which turns on
memory T -
cells, this is what Dr. Megson decided to give her patients.
In a normal brain, vitamin B12 allows
cells to
form new connections, a process that allows
memory formation.
Not only do they block fat
cells from
forming, but they've also been know to prevent cancer, diabetes, and
memory loss due to old age.
Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve
cell maintenance, growth and repair.,, Most pertinent to anyone looking to enhance their aptitude for learning, nitric oxide - induced blood flow also makes
forming new
memories physically possible as it plays a key role in what neurologists call long - term potentiation, a process required for assembling and reinforcing new synaptic connections throughout the entire cerebral cortex, striatum, and hippocampus.