Sentences with phrase «memory in aging mice»

A companion study published by the Buck Institute for Research on Aging in the same issue of Cell Metabolism shows that a ketogenic diet extends longevity and improves memory in aging mice.

Citation: Ketogenic diet reduces mid-life mortality and improves memory in aging mice DOI: 10.1016 / j.cmet.2017.08.004

Not exact matches

Instead of impairing learning and memory, as it does in young people, the drug appears to reverse age - related declines in the cognitive performance of elderly mice.

To find out more about what underlies the cognitive decline that occurs with ageing, André Fischer of the European Neuroscience Institute in Göttingen, Germany, and colleagues analysed DNA from the brains of both young and old mice that had been set tasks involving learning and memory.

A genetic switch linked to memory impairment in ageing mice has been flipped back on, restoring failing brains to a more youthful state.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

Researchers from the Institute of Neurosciences at the Universitat Autònoma de Barcelona (INc - UAB) and the Vall d'Hebron Research Institute (VHIR) are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age - related learning and memory problems in mice.

But low doses of the active ingredient in cannabis, THC, might have the opposite effect on the elderly, reversing brain ageing and restoring learning and memory — at least according to studies of mice.

Finally, the study data suggest that RbAp48 protein mediates its effects, at least in part, through the PKA - CREB1 - CBP pathway, which the team had found in earlier studies to be important for age - related memory loss in the mouse.

«The fact that we were able to reverse age - related memory loss in mice is very encouraging,» said Dr. Kandel.

The study, conducted in postmortem human brain cells and in mice, also offers the strongest causal evidence that age - related memory loss and Alzheimer's disease are distinct conditions.

Here, we've caused age - related memory loss in the mouse, and we've shown it to be relevant to human aging.»

Researchers from the INc - UAB and the VHIR are the first to demonstrate that regulation of the brain's Klotho gene using gene therapy protects against age - related learning and memory problems in mice.

To determine whether RbAp48 plays an active role in age - related memory loss, the researchers turned to mouse studies.

The researchers have identified a protein — RbAp48 — that, when increased in aged wild - type mice, improves memory back to that of young wild - type mice.

In fact, in the case of one type of age - related memory loss — again, distinct from Alzheimer's — researchers were able to restore memory function in mice so that it was comparable to that of young micIn fact, in the case of one type of age - related memory loss — again, distinct from Alzheimer's — researchers were able to restore memory function in mice so that it was comparable to that of young micin the case of one type of age - related memory loss — again, distinct from Alzheimer's — researchers were able to restore memory function in mice so that it was comparable to that of young micin mice so that it was comparable to that of young mice.

Allopregnanolone restores hippocampal - dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice.

This new study investigates this in old mice showing signs of age - related worsening of memory function.

Results from this two - day water maze show that AD mice take considerably longer to find the hidden platform on Day 2 than AD mice treated with J147 for three months (Figure 1A), demonstrating that J147 significantly improved the spatial navigational memory in aged, transgenic AD mice.

Pathological hallmarks of AD, including plaques and loss of synaptic markers, are readily apparent at nine months of age in huAPP / PS1 mice along with clear deficits in spatial memory when compared to wild type controls [7, 10, 11, 31].

Using a technique called parabiosis, in which the vascular systems of two mice are surgically connected, Villeda's lab had previously discovered that infusing old mice with the blood of younger mice leads to brain rejuvenation, including improvements in learning and memory, while infusions of old blood cause premature brain aging in young mice.

Walter said he is looking for scientists to collaborate with in new studies of cognition and memory in mouse models of neurodegenerative diseases and aging, using ISRIB or related molecules.

Aged C3 - deficient mice also performed significantly better than WT mice in the contextual fear conditioning task, which evaluates memory associated with aversive stimuli, and C3 - deficient mice display reduced anxiolytic behavior, evaluated via the elevated plus maze and open - field assessment.

Here we show that vaccination with A beta protects transgenic mice from the learning and age - related memory deficits that normally occur in this mouse model for Alzheimer's disease.

c - Fos imaging of testing - induced brain activations showed that the deterioration of young memory was associated with dentate gyrus dysconnectivity, reminiscent of that seen in aged mice.

Estradiol increased performance in young and aged mice under minimized organizational demand, but failed to improve the age - associated memory impairment and diminished performance in young mice under high organizational demand.

We here studied, in intact young and aged adult mice, drinking - water (1μM) estradiol effects on both retention and organizational components of hippocampus - dependent memory, using a radial - maze task of everyday - like memory.

SAN FRANCISCO, CA — A new study from the Gladstone Institutes has revealed a way to alleviate the learning and memory deficits caused by apoE4, the most important genetic risk factor for Alzheimer's disease, improving cognition to normal levels in aged mice.

In mice engineered to develop Alzheimer's - like symptoms, alternate - day fasting begun in middle age delayed the onset of memory problems by about six monthIn mice engineered to develop Alzheimer's - like symptoms, alternate - day fasting begun in middle age delayed the onset of memory problems by about six monthin middle age delayed the onset of memory problems by about six months.

In Silas» renditions of Bat Masterson, Rawhide, Yogi Bear, The Mickey Mouse Club, and other once popular melodies, she enacts rituals of self - intimacy and creates a commentary on aging, memory and the inevitable advancement of time, while reminding us of the peculiar cultural productions that hold us together generationally and mark the movement from one generation to the next.