Sentences with phrase «merozoite cell surface»

While erythrocyte invasion is a rapid process, the brief extracellular exposure of merozoites outside of their intra-erythrocytic niche places them in direct contact with host antibodies, which contribute to naturally acquired immunity to malaria [8, 9]; therefore, merozoite cell surface and secreted proteins have long been considered attractive targets for rational vaccine development.

The putative merozoite cell surface and secreted proteins that were chosen for recombinant expression

The publication of the P. falciparum genome project in 2002 [10] identified the full complement of parasite proteins but progress in understanding the function of these proteins, including those displayed on the merozoite cell surface, has been hindered by the technical difficulties in expressing Plasmodium proteins in a functionally active form [11].

The proteins displayed on the merozoite cell surface have long been considered attractive vaccine targets because of their direct exposure to host antibodies; however, progress in understanding the functional role of these targets has been hindered by technical challenges associated with expressing these proteins in a functionally active recombinant form.

Not exact matches

Working towards a comprehensive library of cell surface and secreted P. falciparum merozoite proteins, this manuscript describes the identification and characterization of an additional 20 proteins.