Anne Meyer (Reichmann, TUD)-- «Intracellular signaling pathways in the dopaminergic specification of
fetal mesencephalic neural stem cells» (2009)
The TRANSEURO trial of fetal ventral
mesencephalic cell grafts has already implanted cells in its first patient, using improved patient selection, cell sourcing, and graft techniques.
Fetal
mouse mesencephalic NPCs generate dopaminergic neurons from post-mitotic precursors and maintain long - term neural but not dopaminergic potential in vitro.
Initiation of dopaminergic differentiation of Nurr1 -LRB--)
mesencephalic precursor cells depends on activation of multiple mitogen - activated protein kinase pathways.
The purpose of this review is to present electrophysiological and biochemical data showing that endogenous 5 - HT and pharmacological 5 - HT ligands modify
the mesencephalic DA systems» activity.