Sentences with phrase «mesenchymal subpopulation»

This is at least suggested by the observation that the mesenchymal subpopulation in the HMLE model remains viable upon most chemotherapeutic treatment regimens, under conditions that allowed the effective elimination of the epithelial population [7].

Therefore, to overcome chemoresistance mediated by EMT, drug screening efforts have focused on eliminating the mesenchymal subpopulation by searching for drugs with preferential cytotoxic effects on mesenchymal, rather than epithelial HMLE subpopulations [7].

Using an in vitro proxy assay, i.e. the ability of single cells to generate multicellular spheres in suspension (mammosphere assay), it was determined that the mesenchymal subpopulation of HMLE cells is enriched for mammosphere - forming cells.

Not exact matches

Indeed, BH3 inhibitors were capable of eliminating not only the epithelial subpopulation of HMLEs, but also the mesenchymal HMLEs.

Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment.

Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells.

Expression of epithelial - mesenchymal transition (EMT)- associated markers in the total cell population and the cycling hypoxia - selected subpopulation.

Furthermore, the cycling hypoxia - selected F3 subpopulations had increased mRNA levels of three mesenchymal transcription factors - Snail (7 - to 10-fold), Slug (2 - to 3-fold), and Twist (2 - to 4-fold)- as measured by qRT - PCR (Figure 6d).