Sentences with phrase «mesenchymal subtypes»

Nevertheless, the brain tumors that form closer to the SVZ tend to be proneural or neural subtypes, while tumors form farther from the SVZ tend to be classical or mesenchymal subtypes.

This study shows that the mesenchymal subtype is the most aggressive subtype, that it has the poorest prognosis among affected patients, and that cancer stem cells isolated from the mesenchymal subtype have significantly higher levels of the enzyme ALDH1A3 compared with the proneural subtype.

Not exact matches

Genetic analyses have shown that high - grade gliomas can be divided into four subtypes: proneural, neural, classic and mesenchymal.

The researchers then used microarray analysis and pre-clinical animal assays to identify two predominant glioblastoma subtypes, proneural and mesenchymal.

One GSC subtype called the mesenchymal GSC is more malignant and the most therapy - resistant, so Nakano and fellow researchers reasoned that identifying the regulatory molecules active in mesenchymal GSCs might lead to novel and effective therapeutics.

In contrast, mesenchymal and classical glioblastoma subtypes tend to develop farther from this region.

The number of mutations within each tumor and the prevalence of the basal - like and mesenchymal stem - like subtypes — all of which suggest more aggressive tumors — was also greater in the tumors of African American patients.

Bone morphogenetic protein and Notch signalling crosstalk in poor ‐ prognosis, mesenchymal ‐ subtype colorectal cancer.