Sentences with phrase «mesodermal midline»

The molecular fingerprint of Platynereis mesodermal midline cells.

Although none of the genes were exclusively expressed in the annelid mesodermal midline, their combined coexpression was unique to these cells (implying that mesodermal midline in annelids and chordamesoderm in vertebrates are more similar to each other than to any other tissue).

By looking for cell populations that would resemble the vertebrate chordamesoderm (a population of mesodermal midline cells that converge medially to give rise to the notochord; red in Fig. 1A), we identified segmental pairs of mesodermal cells on the non — bone morphogenetic protein (BMP) body side (5) that stood out by early and continuous expression of colA1, encoding collagen type A (Fig. 2, A to D).

Yet, in the absence of detailed investigations of expression profile and developmental fate of mesodermal midline cells in basal ecdysozoans and deuterostome ambulacrarians, the nature of ventral midline tissue in urbilaterians remains undecided.

Last, the Platynereis mesodermal midline is devoid of paraxis, which is exclusively expressed in laterally adjacent mesoderm (fig.

Ancestral state reconstruction suggests that contractile mesodermal midline cells existed in bilaterian ancestors.

We next compared the developmental fate of annelid and vertebrate mesodermal midline cells.

Read from bottom to top, it depicts critical events in the evolution of the mesodermal midline beginning many millions of years ago.

S9) revealed that, after elongation, the Platynereis mesodermal midline cells differentiate into the previously described «medial ventral longitudinal muscle» (13)(Fig. 3A).

Consistently, we observed nuclear localization of β - catenin in the more - lateral mesoderm only, and β - catenin overactivation converted the mesodermal midline toward a more lateral fate and position (fig.

The unique location, large size, and specific arrangement of the Platynereis mesodermal midline cells allowed their unambiguous identification after whole - mount in situ hybridization (WMISH) and thus expression profiling by confocal imaging.

These comparative data suggest that a similar population of mesodermal midline cells already existed in urbilaterian ancestors but leave open its ancient developmental fate.

Not exact matches

We identify a population of mesodermal cells in a developing invertebrate, the marine annelid Platynereis dumerilii, that converges and extends toward the midline and expresses a notochord - specific combination of genes.

However, unlike in chicken (10), the annelid mesodermal and ectodermal midline populations are not directly related by lineage (fig.

Our study of annelid development reveals a population of mesodermal cells that converge and extend along the ventral midline and express a combination of transcription factors, signaling molecules, and guidance factors that closely matches that of the vertebrate chordamesoderm.