Sentences with phrase «metabilism on cellular function»

«These slight alterations may contribute to disease progression and cause cascading effects on the cellular functions that prevent wound healing and eventually contribute to vision impairment.»

Heather Mortiboys (Reichmann, TUD)-- «Influence of mitochondrial energy metabilism on cellular function: implication for neurometabolic and neurodegenerative diseases» (2006)

Analysis of targeted mutation in DJ - 1 on cellular function in primary astrocytes.

She is interested in human genetic variation and its effects on cellular functions linked to infectious and autoimmune disease.

To deduce the role of the Pap operon proteins on cellular function, the researchers performed a «knockout» of the entire operon.

Its impact on cellular function may also interrupt cues for cardiovascular disease, neurodegenerative disease and ageing.

Cellular detox, or what I call «True Cellular Detox,» has gained more acceptance in the last several years due to the increasing number of new studies on cellular function and its relationship to the majority of conditions that we see today.

Not exact matches

Leading clinical investigations seeking to address cardiovascular risk reduction beyond lowering LDL - C focus on interrupting the atherosclerotic process (e.g., plaque formation and instability) by beneficially affecting other lipid, lipoprotein and inflammation biomarkers and cellular functions thought to be related to atherosclerosis and cardiovascular events.

the human body does not know how to run cellular functions on factory made food.

The fields within biology are further divided based on the scale at which organisms are studied and the methods used to study them: biochemistry examines the fundamental chemistry of life; molecular biology studies the complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms interrelate.

Peptides can bind to targets on a cell (usually receptors or enzymes that are themselves proteins) and so regulate cellular functions such as nutrient uptake or communication between cells.

The most famous is the gene ontology, in which categories are assigned to genes based on their cellular location, molecular function, and biological process.

Calcium, however, puts a strain on cells — it is known to hinder protein - folding and metabolism when it accumulates — disrupting normal cellular function.

At first it was thought that only functioned as cellular debris warehouses but in recent years has been that could have an important role as a messenger between cells of the body and now many groups focus their research on the role that could be played exosomes in various diseases, including cancer.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

Named after the IBM Blue Gene supercomputer it relies on, the Blue Brain Project has started modelling — in every detail — the cellular infrastructure and electrophysiological interactions within the cerebral neocortex, which represents about 80 % of the brain and is believed to house cognitive functions such as language and conscious thought.

His pioneering research has focused on defining the cellular and molecular nature of immune exhaustion — the failure of normal immune system function — in chronic infection and cancer.

The goal of the NIH program, as described on its website, is «to understand the principles behind the three - dimensional organization of the nucleus in space and time (the fourth dimension), the role nuclear organization plays in gene expression and cellular function, and how changes in the nuclear organization affect normal development as well as various diseases.»

Previously, understanding a patient's condition relied on analysis of symptoms and signs, such as lung function measurements and airway hyper - responsiveness, but now clinicians can access information about a range of other underlying complex biological traits, including cellular and molecular traits.

Composed of a vast array of different cells, the brain depends on a complex orchestra of cellular functions to carry out its tasks.

Crucially, the team also showed that a serotonergic neuron's gene expression and function depend not only on its location in the adult brain stem, but also on its cellular ancestor in the developing brain.

The major goals of this project are to determine the combined influences of light and gravity on plant development through the identification of changes in the mechanisms and regulation of essential cellular functions.

The new consortium proposes to characterize and tag the 1486 known transcription factors — proteins that switch genes on and off — in the mouse genome, as well as an estimated 600 coregulators that chip in to control cellular and biological functions through networks called regulons.

The study is the first, say its authors, to provide evidence that adenosine, a biochemical at the heart of human cellular function, plays another crucial role — keeping on hand a steady number of healthy chondrocytes, the cells that make and sustain cartilage.

Yang and co-author Chunru Lin, Ph.D., an assistant professor in the same department, confirmed four sites for phosphorylation, a process that turns protein enzymes off and on, impacting key cellular functions.

My lab is investigating the normal cellular functions of signaling pathways implicated in neurological disease, with an emphasis on axon growth and guidance.

The American Journal of Physiology - Heart and Circulatory Physiology focuses on the physiology of the heart, blood vessels and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular and molecular levels.

Our current research focuses on identifying the molecular and cellular interface that blood proteins use to interact with and change the functions of cells in the nervous system.

It concentrates on analysis of gene function at all levels: the gene and its product, the cell and cellular interactions, embryonic tissues and the entire animal.

The laboratory's interest is the stress response and the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of DNA - based motors using a combination of biochemical, biophysical and structural techniques.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

Building on these extreme examples that emphasize the potential roles played by healthy lysosomes in protecting neurons against the age - dependent accumulation of toxic cellular debris, we ultimately seek to understand how neurons sense and regulate the status of their lysosomes, how lysosomes are affected during age - related disease states and whether lysosomal function can be modulated for therapeutic purposes.

Next steps: Future measurements will focus on identifying structural changes in the core complex of RNAP that modulate its cellular localization and function.

Ohsumi and his students, postdocs, and collaborators have had an outsized influence on this field, not only in identifying the genes that underlie cellular recycling, but in revealing many of the molecular details of how these players function.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

He founded Gladstone's multi-pronged research program on Alzheimer's in 1998, and has since identified molecular and cellular processes by which amyloid - beta proteins, which accumulate in the brains of Alzheimer patients, impair cognitive functions.

Tissues and cells are constantly bombarded by a complex array of environmental factors that can have deleterious effects on many critical cellular functions.

Topics such as the mechanisms of cell injury in normal and dystrophic muscle, compensatory muscle regeneration and hypertrophy, and the effects of various therapies or voluntary exercise on muscle repair, satellite cell activation, muscle growth, bone density and age - related atrophy are examined using a large variety of cellular, molecular and whole - animal in vivo assays of function.

As we gain a deeper understanding of the cellular regulation mechanisms of Tau function, we will shed more light on the complex role of Tau in the aetiopathogenesis of neurodegeneration.

The Environmental Influences on Health and Disease Group at Sanford Research studies how environmental factors influence cellular function and human disease, an important interface between chemistry, molecular and cell biology, and physiology.

As part of the Genomics, Development and Disease Section (GDDS), Dr. Loftus» research focus is on understanding the cellular processes regulating melanocyte function.

And nanoscale imaging of the brain promises to open up a brave new world of questions about brain function and structure on a cellular and subcellular level.

Computational Algorithms and Tools (Bruce Aronow, Section Editor): This section focuses on the generation of databases, analysis tools, or large scale analyses carried out from new or established datasets that generate hypotheses into the structure and function of physiological systems at the sub cellular or organismal level.

We focus on proteins, since most cellular functions are carried out by proteins.

Vignali and his colleagues used a variety of molecular and cellular techniques to show that Sema4a binding to Nrp1 turns on a biochemical pathway in mouse regulatory T cells that enhances their function, stability and survival.

Something as radical as making inanimate objects move isn't easy, but many researchers believe that commanding shape change will be invaluable as technology aids and replaces human functions: «Maybe every essential process of life is based on shape transformation: cellular division, the beating of a heart, embryogenesis,» says Nathalie Katsonis, a materials scientist at the University of Twente.

But even using animal cells can be a terrific way to test and research the effect of experimentation on humans: Many of the cellular processes and functions are quite similar between organisms.

They suggest that the effects on lysosomes are secondary to reduced Aβ accumulation, but I suspect the causation may work in the reverse direction, since they found that HBCD lowered cellular membrane cholesterol, and abnormally high lysosomal membrane cholesterol can impair the acidification and function of lysosomes, which are necessary for clearance of intracellular Aβ.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

Lymph is a highly underrated circulatory system within the body and it is responsible for detoxifying waste from the skin on a cellular level, in addition to its many, many other functions.