Certain rare, inherited, genetically based, diseases that cause muscle destruction can also be the cause of high CK levels (primary
metabolic myopathies, myotonia congenita, etc.).
These are the muscular dystrophies (among which are Duchenne and Becker); motor neuron diseases (including ALS and SMA); the peripheral nerve disorders (CMT and Friedreich's ataxia); inflammatory
myopathies; disorders of the neuromuscular junction;
metabolic diseases of muscle as well as other
myopathies.
Myopathies are frequent diseases and can be caused by inherited genetic defects (e.g., muscular dystrophies), or by endocrine inflammatory (e.g., polymyositis), and
metabolic disorder.
Other side effects may include aggression, altered serum creatinine levels, anorexia, anxiety, burping, confusion, constipation, depression, drowsiness, elevated liver enzymes, fainting, fever, headaches, heat intolerance, increased cortisol or insulin levels, increased symptoms of deep vein thrombosis, jaundice, lightheadedness, liver injury, mania,
metabolic acidosis,
myopathy (muscle disease), rhabdomyolysis (muscle breakdown), seizures, skin rashes, vomiting, worsening sleep problems, yellowing of the skin irregular heart rhythm (arrhythmia) and pigmented purpuric dermatosis [3,6].