«Using improved computer software, we have enhanced gene predictions and secondary
metabolite gene cluster predictions in both species to a level not found in most other filamentous fungal species,» says Robert King, the team's lead bioinformatician at Rothamsted.
Not exact matches
The team discovered, for instance, that F. venenatum does not contain some
clusters of
genes that produce subsidiary compounds, or secondary
metabolites, which are produced by F. graminearum during successful wheat infection.
The scientists engineer lab bacteria to express those
gene clusters and then characterize bioactive
metabolites the microbes produce.
Analysis of the chromosome sequences identified 49 putative specialized
metabolite biosynthetic
gene clusters.