Sentences with phrase «metastatic human breast cancer»

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

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Compared to a control (left), epalrestat treatment (right) reduces the number of metastatic tumors (arrowheads) in the lungs of mice injected with human basal - like breast cancer cells.

She expects she will find laminum - 8 uniquely overexpressed in other invasive cancers, like lung and colon cancer, but to date she has tested for it in only human brain and metastatic breast cancer.

Additional experiments using a combination of maraviroc and a drug that blocks the VEGF protein suggest that the treatment duo could be an effective way to prevent metastatic disease in human breast cancer patients, according to the researchers.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

Therefore, his team, led by postdoctoral fellow Gayatri Arun, set out to discover what would happen if mice that model human metastatic breast cancer were bred with the mice lacking Malat1.

Now, University of Pennsylvania researchers have revealed how a reduction in mitochondrial DNA content leads human breast cancer cells to take on aggressive, metastatic properties.

Review of «Antitumor Effects of CD40 Ligand - Expressing Endothelial Progenitor Cells Derived From Human Induced Pluripotent Stem Cells in a Metastatic Breast Cancer Model» from Stem Cells TM by Stuart P. Atkinson.

Zena Werb, University of California, San Francisco, USA Single - cell analysis reveals a stem - cell program in human metastatic breast cancer cells.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Conditions for hypoxia / reoxygenation cycles were optimized using two human metastatic breast cancer cell lines (MDA - MB 231 and BCM2).

[i] Gutterman JU, Blumenschein GR, Alexanian R, Yap HY, Buzdar AU, Cabanillas F, Hortobagyi GN, Hersh EM, Rasmussen SL, Harmon M, Kramer M, Pestka S. Leukocyte interferon - induced tumor regression in human metastatic breast cancer, multiple myeloma, and malignant lymphoma.

We have established a technique to generate syngeneic murine metastatic breast cancer model that mimic human breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment breast cancer model that mimic human breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment cancer model that mimic human breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment breast cancer progression (Rashid OM et al, Breast Cancer Research and Treatment cancer progression (Rashid OM et al, Breast Cancer Research and Treatment Breast Cancer Research and Treatment Cancer Research and Treatment 2014).

STAT5 promotes metastasis of human prostate cancer cells (46) and has been implicated in the resistance of metastatic breast cancer cells to targeted therapies (47).

Low levels of a tiny RNA fragment in cells are associated with metastatic breast cancer in humans and increases the aggressive spread of breast cancer in mice, according to researchers at Whitehead Institute for Biomedical Research.