When the researchers did the opposite, turning on a PAK protein in
a metastatic melanoma cell line, they found the cells became even more resistant to inhibitors of the MAPK pathway.
In this study, we present data from screening 810 genetically - modified mouse
lines with the experimental metastasis assay where intravenous delivery of murine
metastatic melanoma B16 - F10
cells was used to assess the formation of pulmonary metastasic foci.