Sentences with phrase «metastatic squamous»

The FDA approved two anti-PD-1 antibodies (nivolumab / Bristol - Myers Squibb and pembrolizumab / Merck & Co.) for metastatic melanoma in 2014, and it extended approval to metastatic squamous non-small cell lung cancer earlier this year.

Currently, the CDK9 inhibitor flavopiridol is being evaluated in several phase I and II clinical trials for its anti-cancer effects either as a single agent or in combination with other drugs in treatment of esophageal cancer, B - cell chronic lymphocytic leukemia, endometrial carcinoma, recurrent / metastatic squamous cell carcinoma and most relevantly, previously treated locally advanced or metastatic breast cancer (http://www.cancernetwork.com/review-article/current-clinical-trials-flavopiridol/page/0/2).

The FDA approved Opdivo ® (nivolumab) for the treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC) after prior therapy.

14255: STAT3 Signaling During Chemo - Radiation for Squamous Cell Carcinoma of the Head and Neck 14340: A Phase II, Randomized, Open - Label, Multi-Center, Global Study of MEDI4736 Monotherapy, Tremelimumab Monotherapy, and MEDI4736 in Combination with Tremelimumab in Patients with Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (SCCHN) 14258: Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA)

Not exact matches

The trial enrolled 361 patients with recurrent or metastatic head and neck squamous cell carcinoma who had not responded to platinum - based chemotherapy, a rapidly progressing form of the disease with an especially poor prognosis, said Dr. Ferris.

Both drugs are approved for treating metastatic melanoma, and Opdivo is also approved for squamous lung cancer.

The Ogretmen laboratory screened previously reported microarray data sets of several human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these samples, only the levels of CerS4 were significantly decreased.

They discovered that people with both head and neck squamous cell carcinoma and the KRAS - variant who were treated with standard treatment, but not with cetuximab, had a higher risk of failing treatment and developing metastatic disease, meaning the cancer spreads to distant organs and is incurable.

The FDA granted approval to nivolumab (Opdivo), an anti-PD-1 checkpoint inhibitor, for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) that has progressed despite platinum - based chemotherapy.

HPV is also associated with most oropharyngeal squamous cell carcinomas (OPSCCs), a disease in which distant metastatic disease can occur in up to 10 % of patients.

The Program specializes in the treatment of primary head and neck cancers, brain and spine tumors such as squamous cell carcinoma, basal cell cancer, glomus tumor, paragangliomas, acoustic neuromas, salivary gland and mucosal tumors, astrocytomas, oligodendrogliomas, glioblastomas, and hemangioblastomas, and metastatic tumors that may have arisen from elsewhere in the body such as the breast, lung, or prostate.

In March, the U.S. Food and Drug Administration approved nivolumab for patients with advanced (metastatic) squamous non-small cell lung cancer.

Squamous cell carcinoma (SCC) comprises 17 - 25 % of oral tumors seen in the dog and is generally very locally invasive with approximately 10 - 30 % cases developing metastatic disease.